Studies of the immune response against a polyoma virus-induced fibrosarcoma in BALB mice using the Winn's tumor neutralization assay.

Rejection of a polyoma-virus induced fibrosarcoma was studied by the adoptive tumor neutralization assay. This assay showed that polyoma immune spleen cells had a specific growth inhibiting effect on admixed polyoma tumor cells; they only delayed the tumor growth of an irrelevant cell line. We provide evidence both for the role of T-cells in this rejection and for a possible participation of macrophages. T-cells action was not strictly H-2 restricted but H-2 preference was observed. Adoptive protection of nude mice showed that T-cells of the recipient did not participate in the reaction.