生长激素释放激素。对足月人类新生儿脐带血的研究。

Growth hormone-releasing hormone. Studies in cord blood from term human newborns.

作者信息

Argente J, Acquafredda A, Cavallo L, Donnadieu M, Evain-Brion D

机构信息

INSERM U-188, Hôpital Saint-Vincent-de-Paul, Paris, France.

出版信息

Biol Neonate. 1987;52(5):264-7. doi: 10.1159/000242718.

DOI:10.1159/000242718

PMID:3118971

Abstract

Plasma growth hormone-releasing hormone (GHRH) was measured by radioimmunoassay in the cord blood from 32 healthy human newborns after 38-41 weeks of gestation. All were born by uncomplicated vaginal delivery. The GHRH levels in cord blood were 78.33 +/- 8.35 pg/ml at 40 weeks of gestation, approximately threefold higher than the levels at 38 weeks of gestation (27.00 +/- 2.55 pg/ml). No significant differences were found between girls and boys. The rise of plasma GHRH levels in cord blood of the full-term newborns between 38 and 40 weeks of gestation suggests a role of this peptide in the neonatal growth regulation.

摘要

采用放射免疫分析法检测了32例孕38 - 41周健康人类新生儿脐带血中的血浆生长激素释放激素（GHRH）。所有新生儿均通过无并发症的阴道分娩出生。妊娠40周时脐带血中GHRH水平为78.33±8.35 pg/ml，约为妊娠38周时水平（27.00±2.55 pg/ml）的三倍。男女之间未发现显著差异。妊娠38至40周足月新生儿脐带血中血浆GHRH水平的升高表明该肽在新生儿生长调节中起作用。