l -( -) -奎那醇作为配体用于选择性铜（0）催化含氮杂环的 N-芳基化反应。
l -( -) -Quebrachitol as a Ligand for Selective Copper(0)-Catalyzed N-Arylation of Nitrogen-Containing Heterocycles.
机构信息
Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education , Shenyang Pharmaceutical University , Shenyang 110016 , China.
Yunnan Institute of Tropical Crops , Jinghong 666100 , China.
出版信息
J Org Chem. 2019 Jun 21;84(12):8160-8167. doi: 10.1021/acs.joc.9b00997. Epub 2019 Jun 13.
PMID:31190531
Abstract
l-(-)-Quebrachitol (QCT) has been found as a ligand of copper powder for selective N-arylation of nitrogen-containing heterocycles with aryl halides. Furthermore, another potential catalytic system (copper powder/QCT/ t-BuOK) was successfully adapted to unactivated aryl chlorides.
摘要
l-(-)-奎那醇 (QCT) 已被发现为铜粉的配体，可用于芳基卤化物对含氮杂环的选择性 N-芳基化。此外，另一种潜在的催化体系（铜粉/QCT/t-BuOK）成功地适应了未活化的芳基氯。
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