Saddiq Amna A, Mohamed Azza M
Biology Department, Faculty of Science-Al Faisaliah, King Abdulaziz University, Jeddah, Saudi Arabia.
Biochemistry Department, Faculty of Science-Al Faisaliah, King Abdulaziz University, Jeddah, Saudi Arabia.
Dose Response. 2019 May 20;17(2):1559325819850425. doi: 10.1177/1559325819850425. eCollection 2019 Apr-Jun.
Many plant-derived compounds have been used to treat microbial infections. a common cause of many organ infections, has generated increasing concern due to its resistance to antibacterial drugs. This work was carried out to explore the susceptibility of 6 strains (LN872136, LN872137, LN871238, LN871239, LN872140, and LN871241) of methicillin-resistant to aqueous extract of seeds in vitro. Various concentrations (5-20 mg/mL) were used to evaluate the effect of the extract on bacteria growth via the assessment of the microbial biomass and the inhibition zone (IZ). The results showed that the plant extract at 15 or 20 mg/mL, significantly decreased the the biomass of strains after 24 or 48 hours exposure period. (LN871241) showed the largest IZ at 20 mg/mL and documented by scanning electron microscope. The current work may suggest that seed extract can be candidate as a promising antimicrobial agent to treat infection with methicillin-resistant .
许多植物源化合物已被用于治疗微生物感染。作为许多器官感染的常见病因,因其对抗菌药物的耐药性而日益受到关注。本研究旨在探讨6株耐甲氧西林菌株(LN872136、LN872137、LN871238、LN871239、LN872140和LN871241)对种子水提取物的体外敏感性。通过评估微生物生物量和抑菌圈(IZ),使用不同浓度(5 - 20 mg/mL)来评价提取物对细菌生长的影响。结果表明,在15或20 mg/mL浓度下,植物提取物在暴露24或48小时后显著降低了菌株的生物量。(LN871241)在20 mg/mL时显示出最大的抑菌圈,并通过扫描电子显微镜进行了记录。目前的研究可能表明,种子提取物有望成为治疗耐甲氧西林感染的有前景的抗菌剂。