Shih M S, Anderson C
Department of Pathology, University of Western Ontario, London, Canada.
Calcif Tissue Int. 1987 Oct;41(4):187-91. doi: 10.1007/BF02555237.
Bone remodeling activities were assayed on undecalcified sections of iliac crest biopsies obtained from patients with primary biliary cirrhosis (PBC) (n = 25), postmenopausal osteoporosis (n = 64), and age, sex-matched, nonosteoporotic peri- and postmenopausal subjects (n = 26). Thorough semiautomated static and dynamic bone histomorphometry was carried out. Statistical analysis was performed among the age-matched groups in 10-year intervals through the ages 45 to 74. No osteomalacia or osteoporotic condition was detected in the patients with PBC. Our data have shown they did not have a mineralization defect but rather high bone turnover rates. The discrepancy of our observations to other published studies is discussed. We suggest that the osteoporotic condition attributed by others to PBC may just be the result of the concomitant aging processes.
对取自原发性胆汁性肝硬化（PBC）患者（n = 25）、绝经后骨质疏松症患者（n = 64）以及年龄和性别匹配的非骨质疏松性围绝经期和绝经后受试者（n = 26）的髂嵴活检未脱钙切片进行骨重塑活性检测。进行了全面的半自动静态和动态骨组织形态计量学分析。在45至74岁的年龄组中，以10年为间隔进行了年龄匹配组间的统计分析。PBC患者未检测到骨软化症或骨质疏松症。我们的数据表明，他们没有矿化缺陷，而是具有高骨转换率。讨论了我们的观察结果与其他已发表研究的差异。我们认为，其他人归因于PBC的骨质疏松症可能只是伴随衰老过程的结果。
