Gaul U, Jäckle H
Max-Planck-Institut für Entwicklungsbiologie, Abteilung Biochemie, Tübingen, Federal Republic of Germany.
Cell. 1987 Nov 20;51(4):549-55. doi: 10.1016/0092-8674(87)90124-3.
We examined the protein domain of the gap gene Krüppel (Kr) in mutants that affect the establishment of different regions of the segment pattern along the longitudinal axis of the Drosophila embryo. Our data suggest that Kr provides cues for establishing the "central" pattern elements at the blastoderm stage, and that Kr activity is controlled by maternal effect genes acting at the poles. The formation of the Kr protein domain may involve ubiquitous activation of Kr gene expression which, however, is limited by region-specific repression through the action of the maternal anterior and posterior pattern organizer genes. In addition, the formation of the Kr protein domain depends on the activity of gap genes acting adjacent to the Kr domain, but it is independent of subordinate pair-rule gene activities.
我们研究了间隙基因Krüppel（Kr）的蛋白质结构域，该研究针对的是影响果蝇胚胎纵轴上节段模式不同区域建立的突变体。我们的数据表明，Kr为在囊胚期建立“中央”模式元件提供线索，并且Kr活性受作用于两极的母体效应基因控制。Kr蛋白质结构域的形成可能涉及Kr基因表达的普遍激活，然而，这种激活受到母体前后模式组织者基因作用导致的区域特异性抑制的限制。此外，Kr蛋白质结构域的形成取决于与Kr结构域相邻作用的间隙基因的活性，但它独立于从属的成对规则基因的活性。
