肺炎球菌血清型转换的复杂性。
The complexity of serotype replacement of pneumococci.
机构信息
Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary.
出版信息
Hum Vaccin Immunother. 2019;15(11):2725-2728. doi: 10.1080/21645515.2019.1621068. Epub 2019 Jun 13.
Abstract
Pneumococci respond extremely rapidly to the vaccine pressure created by the conjugate vaccines (PCVs). Vaccine serotypes are disappearing, meanwhile new, often previously very rare types are emerging, and it is difficult to establish what makes certain serotypes more successful in replacement. The situation is very complex: every serotype has different antibiotic sensitivity or invasive capacity. However, despite this dynamic serotype rearrangement, the overall pneumococcal carriage rate remains quite stable, suggesting that these bacterial species can be considered as a commensal colonizer.
摘要
肺炎球菌对结合疫苗（PCV）所产生的疫苗压力反应非常迅速。疫苗血清型正在消失，与此同时，新的、通常以前非常罕见的血清型正在出现，而且很难确定是什么使某些血清型在替代中更成功。情况非常复杂：每种血清型的抗生素敏感性或侵袭能力都不同。然而，尽管存在这种动态的血清型重组，肺炎球菌携带率总体上仍相当稳定，这表明这些细菌可以被认为是一种共生定植者。
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