Rudinsky B F, Komar K J, Strates E, Meadow W L
Department of Pediatrics, Wyler Children's Hospital, University of Chicago, IL 60637.
Crit Care Med. 1987 Dec;15(12):1127-30. doi: 10.1097/00003246-198712000-00010.
No therapeutic agent consistently decreases pulmonary arterial pressure (PAP) more than aortic pressure in neonates with persistent pulmonary hypertension of the newborn. We have investigated whether nitroglycerin (NG) or nitroprusside (NP) selectively decreases PAP in an animal model of sepsis-induced pulmonary hypertension. Piglets were anesthetized, intubated, and ventilated. Pulmonary hypertension was induced by an iv infusion of group B Streptococci. Piglets were then divided into three groups with group B Streptococci infusion ongoing. Neither PAP nor the pulmonary vascular resistance index was decreased significantly by either NP or NG. NP decreased significantly both mean aortic pressure and the systemic vascular resistance index. Cardiac index decreased significantly during both NG and placebo infusion. These data suggest that neither NP nor NG is likely to be beneficial in sepsis-induced pulmonary hypertension in newborns.
在患有新生儿持续性肺动脉高压的新生儿中，没有一种治疗药物能持续降低肺动脉压（PAP）的幅度超过主动脉压。我们研究了硝酸甘油（NG）或硝普钠（NP）在脓毒症诱导的肺动脉高压动物模型中是否能选择性降低肺动脉压。仔猪接受麻醉、插管和通气。通过静脉输注B族链球菌诱导肺动脉高压。然后在持续输注B族链球菌的情况下将仔猪分为三组。NP和NG均未显著降低肺动脉压或肺血管阻力指数。NP显著降低了平均主动脉压和全身血管阻力指数。在输注NG和安慰剂期间，心脏指数均显著下降。这些数据表明，NP和NG在新生儿脓毒症诱导的肺动脉高压中可能都没有益处。
