Meadow W L, Rudinsky B F, Strates E
Dev Pharmacol Ther. 1986;9(4):249-59. doi: 10.1159/000457100.
The effects of intravenous phenylephrine (PE) on aortic blood pressure (AOP), pulmonary artery pressure (PAP), and cardiac output (CO) were evaluated in piglets with normal PAP and piglets with sepsis-induced pulmonary hypertension. Anesthetized, ventilated piglets (1-4 weeks; n = 22) were divided into four groups - group 1 (n = 5) received group B beta streptococci (GBS) followed by PE (300 micrograms/kg); group 2 (n = 6) received GBS alone; group 3 (n = 6) received placebo infusion; group 4 (n = 5) received PE alone (300 micrograms/kg). Infusion of GBS in piglets (groups 1 and 2) elevated PAP by 149 and 176%, reduced CO by 34 and 28%, and did not affect AOP. Administration of PE (groups 1 and 4) raised AOP by 30 and 27% without significantly affecting PAP. However, CO fell after PE by 31 and 39%, respectively. If selective elevation of systemic blood pressure is to become an effective strategy for human newborns with right-to-left shunts caused by sepsis-induced pulmonary hypertension, agents other than PE, with less associated reduction of CO, need to be identified.
在具有正常肺动脉压的仔猪和败血症诱导的肺动脉高压仔猪中，评估了静脉注射去氧肾上腺素（PE）对主动脉血压（AOP）、肺动脉压（PAP）和心输出量（CO）的影响。将麻醉、通气的仔猪（1 - 4周龄；n = 22）分为四组——第1组（n = 5）先接受B族β溶血性链球菌（GBS），然后接受PE（300微克/千克）；第2组（n = 6）仅接受GBS；第3组（n = 6）接受安慰剂输注；第4组（n = 5）仅接受PE（300微克/千克）。给仔猪（第1组和第2组）输注GBS使PAP分别升高149%和176%，使CO分别降低34%和28%，且不影响AOP。给予PE（第1组和第4组）使AOP分别升高30%和27%，而对PAP无显著影响。然而，PE给药后CO分别下降31%和39%。如果选择性升高体循环血压要成为治疗因败血症诱导的肺动脉高压导致右向左分流的人类新生儿的有效策略，就需要确定除PE之外、对CO影响较小的药物。
