日本糖尿病患者空腹血浆胰高血糖素与血清C肽之间的正相关关系。
Positive correlation between fasting plasma glucagon and serum C-peptide in Japanese patients with diabetes.
作者信息
Hosokawa Yoshiya, Kozawa Junji, Nishizawa Hitoshi, Kawamori Dan, Maeda Norikazu, Otsuki Michio, Matsuoka Taka-Aki, Iwahashi Hiromi, Shimomura Iichiro
机构信息
Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.
Medical Education Center, Faculty of Medicine, Osaka University, Suita, Osaka Japan.
出版信息
Heliyon. 2019 May 13;5(5):e01715. doi: 10.1016/j.heliyon.2019.e01715. eCollection 2019 May.
AIMS
Glucagon plays pivotal roles in systemic glucose homeostasis mainly by promoting hepatic glucose output. Using a sandwich enzyme-linked immunosorbent assay (ELISA), we evaluated fasting plasma glucagon levels in hospitalized patients with type 1 or type 2 diabetes, and assessed the relationships between glucagon levels and various clinical parameters.
METHODS
We enrolled adult Japanese diabetes patients admitted to Osaka University Medical Hospital for glycemic control between July 2017 and May 2018 in this study. After patients had fasted for 12 h, blood samples were obtained and plasma glucagon levels were measured using a sandwich ELISA.
RESULTS
Total 107 patients participated in the study. The mean fasting plasma glucagon level of patients with acute onset type 1 diabetes was significantly lower than that of patients with type 2 diabetes ( < 0.05). Plasma glucagon levels were not significantly correlated with plasma glucose levels in patients with type 1 diabetes or in patients with type 2 diabetes. Multiple regression analysis indicated that fasting glucagon levels were independently and significantly correlated with fasting serum C-peptide levels in patients with type 2 diabetes.
CONCLUSIONS
Our results suggest that insulin and glucagon secretion are balanced in the fasting state in patients with type 2 diabetes.
目的
胰高血糖素主要通过促进肝脏葡萄糖输出，在全身葡萄糖稳态中发挥关键作用。我们采用夹心酶联免疫吸附测定法（ELISA），评估了1型或2型糖尿病住院患者的空腹血浆胰高血糖素水平，并分析了胰高血糖素水平与各种临床参数之间的关系。
方法
本研究纳入了2017年7月至2018年5月期间因血糖控制入住大阪大学医学部附属医院的成年日本糖尿病患者。患者禁食12小时后采集血样，采用夹心ELISA法测定血浆胰高血糖素水平。
结果
共有107例患者参与本研究。急性起病1型糖尿病患者的空腹血浆胰高血糖素水平显著低于2型糖尿病患者（<0.05）。1型糖尿病患者或2型糖尿病患者的血浆胰高血糖素水平与血糖水平均无显著相关性。多元回归分析表明，2型糖尿病患者的空腹胰高血糖素水平与空腹血清C肽水平独立且显著相关。
结论
我们的结果提示，2型糖尿病患者在空腹状态下胰岛素和胰高血糖素分泌是平衡的。
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