LeVee Alexis, Trieu Megan, Bhattacharyya Sarathi, Sandhu Gurveen
Department of Medicine, Tufts University School of Medicine, Boston, MA, USA.
Department of Medicine, Ronald Reagan UCLA Medical Center, Los Angeles, CA, USA.
Respir Med Case Rep. 2019 May 15;27:100856. doi: 10.1016/j.rmcr.2019.100856. eCollection 2019.
Amiodarone is an antiarrhythmic agent used primarily to treat atrial and ventricular arrhythmias. However, the drug also has many adverse effects, including pulmonary toxicity, and a wide range of pulmonary diseases have been reported. Amiodarone-induced eosinophilic pneumonia is a relatively rare adverse effect with an incidence ranging between 5 and 13% [1]. The majority of cases have been diagnosed with lung biopsy, with only one prior reported case diagnosed by bronchoalveolar lavage (BAL) [2]. This report describes the second documented case of amiodarone-induced eosinophilic pneumonia diagnosed by eosinophilia on BAL cytology. In this case, complete cessation of symptoms occurred after discontinuation of amiodarone and treatment with corticosteroids. An updated review of the literature of amiodarone-induced eosinophilic pneumonia is also detailed.
胺碘酮是一种主要用于治疗房性和室性心律失常的抗心律失常药物。然而，该药物也有许多不良反应，包括肺部毒性，并且已经报道了多种肺部疾病。胺碘酮诱发的嗜酸性粒细胞性肺炎是一种相对罕见的不良反应，发病率在5%至13%之间[1]。大多数病例通过肺活检确诊，此前仅有1例通过支气管肺泡灌洗（BAL）确诊的报道[2]。本报告描述了第二例通过BAL细胞学检查发现嗜酸性粒细胞增多而确诊的胺碘酮诱发的嗜酸性粒细胞性肺炎病例。在该病例中，停用胺碘酮并使用皮质类固醇治疗后症状完全消失。本文还详细更新了关于胺碘酮诱发的嗜酸性粒细胞性肺炎的文献综述。
