Chen Lian-Yu, Chen Yi-Lung, Tsay Wen-Ing, Wu Shang-Chi, Chen Yen-Tyng, Hsiao Po-Chang, Yu Ya-Hui, Ting Te-Tien, Chen Chuan-Yu, Tu Yu-Kang, Huang Jiun-Hau, Yang Hao-Jan, Li Chung-Yi, Strong Carol, Yen Cheng-Fang, Yen Chia-Feng, Hsu Jui, Chen Wei J
Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, 17 Xu-Zhou Road, Taipei 100, Taiwan.
Department of Addiction Psychiatry and Kunming Prevention and Control Center, Taipei City Hospital, Taipei, Taiwan.
Prev Med Rep. 2019 May 19;15:100900. doi: 10.1016/j.pmedr.2019.100900. eCollection 2019 Sep.
Nonmedical prescription drug use (NMPDU) has become a major public health issue but little is known in Asian populations. This study aimed to investigate the prevalence and correlates of NMPDU in Taiwan. Participants from the 2014 national survey of 17,837 individuals, aged 12 to 64 year, completed anonymously a computer-assisted self-interview. Past-year prescription drug use was divided into medical use only (MUO) and nonmedical use (NMU), defined as using the drug without a prescription, or more frequently, or in larger doses than prescribed. Problematic alcohol use was measured using the Alcohol Use Disorders Identification Test (AUDIT), problematic drug use using the 20-item Drug Abuse Screening Test (DAST), and depressive symptoms using the Center for Epidemiological Study-Depression (CES-D). The prevalence of past-year NMU was 3.02% for analgesics, 0.71% for sedatives/hypnotics, and 3.66% for either drug, with a very small overlap of NMU between analgesics and sedatives/hypnotics (0.07%). When individuals with NMU were compared to those without NMU (Non-NMU) and those with MUO, respectively, some correlates consistently identified, including young adulthood, tobacco smoking, alcohol drinking, and greater AUDIT's scores for analgesics, as well as hard drug use and greater DAST's scores for sedatives/hypnotics. NMU was associated with greater CES-D's scores for both analgesics and sedatives/hypnotics when compared to Non-NMU but not to MUO. Robust correlates of NMPDU could offer implications for development of prevention strategies of NMPDU.
非医疗目的使用处方药(NMPDU)已成为一个重大的公共卫生问题,但在亚洲人群中人们对此了解甚少。本研究旨在调查台湾地区非医疗目的使用处方药的患病率及其相关因素。来自2014年全国性调查的17837名年龄在12至64岁之间的参与者,以匿名方式完成了一次计算机辅助自我访谈。过去一年的处方药使用情况分为仅医疗用途(MUO)和非医疗用途(NMU),非医疗用途定义为无处方使用药物,或更频繁、或超量使用药物。使用酒精使用障碍识别测试(AUDIT)来衡量问题饮酒情况,使用20项药物滥用筛查测试(DAST)来衡量问题药物使用情况,使用流行病学研究中心抑郁量表(CES-D)来衡量抑郁症状。过去一年中,镇痛药的非医疗用途患病率为3.02%,镇静催眠药为0.71%,两种药物的非医疗用途患病率为3.66%,镇痛药和镇静催眠药的非医疗用途重叠率非常低(0.07%)。将有非医疗用途用药的个体分别与无此情况(非NMU)的个体以及有医疗用途用药的个体进行比较时,发现了一些一致的相关因素,包括青年期、吸烟、饮酒,以及镇痛药的AUDIT得分更高,还有使用烈性毒品以及镇静催眠药的DAST得分更高。与非NMU个体相比,镇痛药和镇静催眠药的非医疗用途均与CES-D得分更高相关,但与医疗用途用药个体相比则不然。非医疗目的使用处方药的有力相关因素可为制定预防策略提供参考。