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欧盟处方药的非医疗用途。

Nonmedical use of prescription drugs in the European Union.

作者信息

Novak Scott P, Håkansson Anders, Martinez-Raga Jose, Reimer Jens, Krotki Karol, Varughese Sajan

机构信息

Behavioral Epidemiology, RTI International, 3040 East Cornwallis Road, Research Triangle Park, NC, 27709, USA.

Division of Psychiatry, Lund University, Malmö, Sweden.

出版信息

BMC Psychiatry. 2016 Aug 4;16:274. doi: 10.1186/s12888-016-0909-3.

Abstract

BACKGROUND

Nonmedical prescription drug use (NMPDU) refers to the self-treatment of a medical condition using medication without a prescriber's authorization as well as use to achieve euphoric states. This article reports data from a cross-national investigation of NMPDU in five European Countries, with the aim to understand the prevalence and characteristics of those engaging in NMPDU across the EU.

METHODS

A parallel series of self-administered, cross-sectional, general population surveys were conducted in 2014. Data were collected using multi-stage quota sampling and then weighted using General Exponential Model. A total of 22,070 non-institutionalized participants, aged 12 to 49 years, in 5 countries: Denmark, Germany, Great Britain, Spain, and Sweden. Lifetime and past-year nonmedical use of prescription medications such as stimulants, opioids, and sedatives were ascertained via a modified version of the World Health Organization's Composite International Diagnostic Interview. Information about how the medications were acquired for NMPDU were also collected from the respondent.

RESULTS

Lifetime and past-year prevalence of nonmedical prescription drug use was estimated for opioids (13.5 and 5.0 %), sedatives (10.9 and 5.8 %), and stimulants (7.0 and 2.8 %). Germany exhibited the lowest levels of NMPDU, with Great Britain, Spain, and Sweden having the highest levels. Mental and sexual health risk factors were associated with an increased likelihood of past-year nonmedical prescription drug use. Among past-year users, about 32, 28, and 52 % of opioid, sedative, and stimulant nonmedical users, respectively, also consumed illicit drugs. Social sources (sharing by friends/family) were the most commonly endorsed methods of acquisition, ranging from 44 % (opioids) to 62 % (sedatives). Of interest is that Internet pharmacies were a common source of medications for opioids (4.1 %), stimulants (7.6 %), and sedatives (2.7 %).

CONCLUSIONS

Nonmedical prescription drug use was reported across the five EU countries we studied, with opioids and sedatives being the most prevalent classes of prescription psychotherapeutics. International collaborations are needed for continued monitoring and intervention efforts to target population subgroups at greatest risk for NMDU.

摘要

背景

非医疗目的使用处方药(NMPDU)是指在没有开处方者授权的情况下自行使用药物治疗疾病以及为达到欣快状态而使用药物。本文报告了对五个欧洲国家非医疗目的使用处方药的一项跨国调查的数据,旨在了解整个欧盟范围内非医疗目的使用处方药者的患病率及特征。

方法

2014年开展了一系列并行的自填式横断面一般人群调查。采用多阶段配额抽样收集数据,然后使用通用指数模型进行加权。共有来自丹麦、德国、英国、西班牙和瑞典五个国家的22070名年龄在12至49岁之间的非机构化参与者。通过世界卫生组织综合国际诊断访谈的一个修改版本确定终生及过去一年中对兴奋剂、阿片类药物和镇静剂等处方药的非医疗使用情况。还从受访者那里收集了有关非医疗目的使用的药物获取方式的信息。

结果

估计阿片类药物的终生及过去一年非医疗目的使用处方药的患病率分别为13.5%和5.0%,镇静剂为10.9%和5.8%,兴奋剂为7.0%和2.8%。德国的非医疗目的使用处方药水平最低,英国、西班牙和瑞典的水平最高。心理和性健康风险因素与过去一年非医疗目的使用处方药的可能性增加相关。在过去一年的使用者中,分别约有32%、28%和52%的阿片类药物、镇静剂和兴奋剂非医疗使用者也使用非法药物。社会来源(朋友/家人分享)是最常被认可的获取方式,范围从44%(阿片类药物)到62%(镇静剂)。有趣的是,网络药店是阿片类药物(4.1%)、兴奋剂(7.6%)和镇静剂(2.7%)的常见药物来源。

结论

在我们研究的五个欧盟国家均报告了非医疗目的使用处方药的情况,阿片类药物和镇静剂是最普遍的处方类精神治疗药物。需要开展国际合作,持续进行监测和干预,以针对非医疗目的使用处方药风险最高的人群亚组。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4173/4972971/f74cee56ebc4/12888_2016_909_Fig1_HTML.jpg

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