Casteleijn David, Steel Amie, Bowman Diana, Lauche Romy, Wardle Jon
University of Technology Sydney, Sydney, Australia.
Klinik für Integrative Medizin und Naturheilkunde, Sozialstiftung Bamberg, Bamberg, Germany.
Integr Med Res. 2019 Jun;8(2):123-128. doi: 10.1016/j.imr.2019.04.007. Epub 2019 Apr 20.
Mental health conditions including anxiety and depression account for around 8% of the global disease burden. Anxiety and depression often coexist and impose a high individual and social burden. Patients with mental and behavioural conditions may be at increased risk of co-morbidities and are often high health-care utilisers. Herbal medicine is estimated to be used by up to 80% of the worlds population, and by 22% of Australian women seeking care for depression. The holistic and tailored treatment approach offered by practitioners of herbal medicine is difficult to capture in randomised controlled trials and as such there is a paucity of research demonstrating the outcomes of real-life practice. This project aims to address this gap with a whole practice, observational model.
METHODS/DESIGN: The study will employ a naturalistic observational design. Two-hundred patient participants will be recruited to be treated by 15 clinician participants from different naturopathic clinics. The observed changes in anxiety and depression symptoms of patients will be documented across three consultations using validated patient-reported outcome measures (SF-36, DASS-21, GHQ-28 and POMS-2).
Clinical studies investigating the efficacy of individualised herbal medicine treatment as prescribed by a naturopath are rare. Our study attempts to fill this gap with a longitudinal observation of individualised care as practiced by naturopaths in Australia; to offer valuable insights into the effectiveness of individualised herbal medicine practice and provide contextualisation of data currently focused on individual herbal medicines in specific conditions.Trial Registration: Australian and New Zealand Clinical Trials Registry: ACTRN12616000010493.
包括焦虑症和抑郁症在内的心理健康状况约占全球疾病负担的8%。焦虑症和抑郁症常常并存，给个人和社会带来沉重负担。患有精神和行为疾病的患者可能合并其他疾病的风险更高，而且往往是医疗保健的高使用者。据估计，世界上多达80%的人口使用草药，在寻求抑郁症治疗的澳大利亚女性中，有22%使用草药。草药医学从业者提供的整体和个性化治疗方法难以在随机对照试验中体现，因此，缺乏研究来证明实际临床实践的效果。本项目旨在通过整体实践观察模型来填补这一空白。
方法/设计：本研究将采用自然主义观察设计。将招募200名患者参与者，由来自不同自然疗法诊所的15名临床医生参与者进行治疗。将使用经过验证的患者报告结局指标（SF-36、DASS-21、GHQ-28和POMS-2），记录患者在三次会诊中焦虑和抑郁症状的观察变化。
调查自然疗法医生开具的个性化草药治疗疗效的临床研究很少。我们的研究试图通过对澳大利亚自然疗法医生实施的个性化护理进行纵向观察来填补这一空白；为个性化草药治疗实践的有效性提供有价值的见解，并对目前针对特定病症的单一草药的数据进行背景分析。试验注册：澳大利亚和新西兰临床试验注册中心：ACTRN12616000010493。
