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预测英格兰性健康诊所中男男性行为者和年轻人的性传播感染诊断:使用常规临床数据进行分诊算法的开发与验证

Predicting STI Diagnoses Amongst MSM and Young People Attending Sexual Health Clinics in England: Triage Algorithm Development and Validation Using Routine Clinical Data.

作者信息

King Carina, Hughes Gwenda, Furegato Martina, Mohammed Hamish, Were John, Copas Andrew, Gilson Richard, Shahmanesh Maryam, Mercer Catherine H

机构信息

Institute for Global Health, University College London, 30 Guilford Street, London, UK.

Department of HIV & STIs, Centre for Infectious Disease Surveillance & Control, Public Health England, 61 Colindale Avenue, London, UK.

出版信息

EClinicalMedicine. 2018 Nov 28;4-5:43-51. doi: 10.1016/j.eclinm.2018.11.002. eCollection 2018 Oct-Nov.

Abstract

BACKGROUND

Sexual health (SH) services increasingly need to prioritise those at greatest risk of sexually transmitted infections (STIs). We used SH surveillance data to develop algorithms to triage individuals attending SH services within two high-risk populations: men who have sex with men (MSM) and young people (YP).

METHODS

Separate multivariable logistic regression models for MSM and YP were developed using surveillance data on demographics, recent sexual history, prior STI diagnoses and drug/alcohol use from five clinics in 2015-2016 to identify factors associated with new STI diagnoses. The models were prospectively applied in one SH clinic in May 2017 as an external validation.

FINDINGS

9530 YP and 1448 MSM SH episodes informed model development. For YP, factors associated with new STI diagnosis (overall prevalence: 10.6%) were being of black or mixed white/black ethnicity; history of chlamydia diagnosis (previous year); and multiple partners/new partner (previous 3-months). The YPs model had reasonable performance (c-statistic: 0.703), but poor discrimination when externally validated (c-statistic: 0.539). For MSM, being of South Asian ethnicity; being born in Europe (excluding the UK); and condomless anal sex or drug use (both in previous 3-months) were associated with STI diagnosis (overall prevalence: 22.0%). The MSM model had a c-statistic of 0.676, reducing to 0.579 on validation.

INTERPRETATION

SH surveillance data, including limited behavioural data, enabled triage algorithms to be developed, but its implementation may be problematic due to poor external performance. This approach may be more suitable to self-triage, including online, ensuring patients are directed towards appropriate services.

FUNDING

NIHR HTA programme (12/191/05).

摘要

背景

性健康(SH)服务越来越需要优先关注性传播感染(STIs)风险最高的人群。我们利用性健康监测数据开发算法,对两个高风险人群——男男性行为者(MSM)和年轻人(YP)中的性健康服务就诊者进行分流。

方法

利用2015 - 2016年来自五家诊所的人口统计学、近期性史、既往性传播感染诊断以及药物/酒精使用情况的监测数据,分别为男男性行为者和年轻人建立多变量逻辑回归模型,以确定与新发性传播感染诊断相关的因素。2017年5月,这些模型在一家性健康诊所进行前瞻性应用,作为外部验证。

结果

9530例年轻人和1448例男男性行为者的性健康就诊情况为模型开发提供了依据。对于年轻人,与新发性传播感染诊断相关的因素(总体患病率:10.6%)包括黑人或黑白混血种族;衣原体诊断史(前一年);以及多个性伴侣/新性伴侣(前三个月)。年轻人模型表现合理(c统计量:0.703),但在外部验证时区分能力较差(c统计量:0.539)。对于男男性行为者,南亚种族;出生在欧洲(不包括英国);以及无保护肛交或药物使用(均在前三个月)与性传播感染诊断相关(总体患病率:22.0%)。男男性行为者模型的c统计量为0.676,验证时降至0.579。

解读

性健康监测数据,包括有限的行为数据,有助于开发分流算法,但由于外部表现不佳,其实施可能存在问题。这种方法可能更适合自我分流,包括在线分流,以确保患者能获得适当的服务。

资金来源

英国国家卫生研究院卫生技术评估项目(12/191/05)。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fda7/6537562/e1d64ea379db/gr1.jpg

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