Aggarwal Payal, Limaiem Faten
The Brooklyn Hospital Center
University of Tunis El Manar, Tunis Faculty of Medicine
Hodgkin lymphoma characteristically presents with Hodgkin and Reed-Sternberg cells. When the cells are mononucleated, they are called Hodgkin cells; when multinucleated, they are called Reed-Sternberg cells. The classic Reed-Sternberg cell is a large cell that can be >50 µm in diameter. This cell is binucleated with prominent eosinophilic nuclei surrounded by abundant cytoplasm. Reed-Sternberg cells were first illustrated incorrectly by Greenfield in a paper published in 1878. Then, in 1898, Carl Sternberg published a German paper that included illustrations of the cells along with a description of their pathology. However, Sternberg believed that Hodgkin's disease was a form of tuberculosis. In 1902, Dorothy Reed described Reed-Sternberg cells in her well-known paper, "On the Pathological Changes in Hodgkin Disease, with Especial Reference to its Relation to Tuberculosis," which included a clear description of the cells and illustrations she made herself. Reed emphasized that Hodgkin's disease was unrelated to tuberculosis, and she used animal inoculation to prove her point. She also showed no immunological response to tuberculin in Hodgkin's disease.
霍奇金淋巴瘤的特征是出现霍奇金细胞和里德-斯腾伯格细胞。当细胞为单核时，称为霍奇金细胞；当为多核时，则称为里德-斯腾伯格细胞。典型的里德-斯腾伯格细胞是一种大细胞，直径可大于50 µm。该细胞双核，嗜酸性核显著，周围有丰富的细胞质。1878年，格林菲尔德在一篇发表的论文中首次错误地描绘了里德-斯腾伯格细胞。1898年，卡尔·斯腾伯格发表了一篇德语论文，其中包括这些细胞的插图以及对其病理学的描述。然而，斯腾伯格认为霍奇金病是结核病的一种形式。1902年，多萝西·里德在她著名的论文《论霍奇金病的病理变化，特别是其与结核病的关系》中描述了里德-斯腾伯格细胞，该论文包括对这些细胞的清晰描述以及她自己绘制的插图。里德强调霍奇金病与结核病无关，她通过动物接种来证明自己的观点。她还表明霍奇金病对结核菌素无免疫反应。
