Böhles H
Universitätskinderklinik, Erlangen.
Infusionsther Klin Ernahr. 1987 Sep;14 Suppl 3:33-6.
During total parenteral alimentation of rats it could be demonstrated that carnitine supplementation in small (10 mg/kg B.W./day) and high (100 mg/kg B.W./day) amounts leads to an increased and only slightly elevated ketogenesis. The lower ketogenicity when carnitine is supplemented in high amounts is explained as a substrate withdrawal as a consequence of an outward transport of long-chain fatty acids in the form of carnitine conjugates from the mitochondrial matrix space. This reaction leads at the same time to an increased availability of mitochondrial CoA.
在对大鼠进行全胃肠外营养期间，可以证明，补充少量（10毫克/千克体重/天）和大量（100毫克/千克体重/天）的肉碱会导致生酮作用增强，且只是略有升高。大量补充肉碱时生酮作用较低，这被解释为由于长链脂肪酸以肉碱共轭物的形式从线粒体基质空间向外转运而导致底物减少。同时，该反应会使线粒体辅酶A的可用性增加。
