Ramsay R R, Arduini A
Department of Biochemistry and Biophysics, University of California, San Francisco.
Arch Biochem Biophys. 1993 May;302(2):307-14. doi: 10.1006/abbi.1993.1216.
The role of carnitine via the action of carnitine acyltransferase in buffering CoA availability in the mitochondrial matrix is well known. There is now sufficient evidence to extend this to a general role. Carnitine can buffer the acylation state of the CoA pool for any type of acyl group that is a substrate for the carnitine acyltransferase family of enzymes. Specific carnitine acyltransferases in each organelle or membrane can modulate the reserves of free CoA and acyl-CoA in ways specific to the local metabolic demands. The use of inhibitors of carnitine acyltransferases in complex systems and in vivo now permits exploration of the consequences of this role.
肉碱通过肉碱酰基转移酶的作用在线粒体基质中缓冲辅酶A可用性的作用是众所周知的。现在有足够的证据将此扩展到一般作用。肉碱可以缓冲辅酶A池对于作为肉碱酰基转移酶家族酶底物的任何类型酰基的酰化状态。每个细胞器或膜中的特定肉碱酰基转移酶可以根据局部代谢需求以特定方式调节游离辅酶A和酰基辅酶A的储备。在复杂系统和体内使用肉碱酰基转移酶抑制剂现在允许探索这种作用的后果。
