Department of Electrical and Computer Engineering, Iowa State University, Iowa, 50011, USA.
Skyworks Solutions, Inc., 01801, USA.
J Nanosci Nanotechnol. 2019 Dec 1;19(12):7591-7595. doi: 10.1166/jnn.2019.16752.
Cost-effective single-walled carbon nanotubes (SWCNTs) and poly(3,4-ethylenedioxythiophene) nanocomposite-microwire (N-MWs) electronic biosensor was fabricated by microlithography and layer-by-layer nanoassembly. Using N-MWs, we not only can achieve accurate large-scale registration and integration of nanoscale materials into a functional device, but also can enhance the sensing surface area significantly, which can open great opportunities for the cost-effectively fabrication of ultrasensitive biosensors. Using the binding assay between Protein A and Rabbit Immunoglobulin G (IgG) as a model, measurements find that the N-MWs electronic biosensor, containing carbon nanotubes (CNTs) and conductive polymers, exhibits field effect and the resistance changes upon its binding to biomolecules. The effect of the dimensions of the N-MWs on the sensitivity of the sensor has also been evaluated.
通过微光刻和层层纳米组装技术，制备出了具有成本效益的单壁碳纳米管（SWCNTs）和聚（3,4-乙撑二氧噻吩）纳米复合-微线（N-MWs）电子生物传感器。使用 N-MWs，我们不仅可以实现纳米级材料的精确大规模注册和集成到功能设备中，而且还可以显著提高传感表面积，这为经济高效地制造超灵敏生物传感器开辟了巨大的机会。使用蛋白 A 与兔免疫球蛋白 G（IgG）之间的结合测定作为模型，测量发现包含碳纳米管（CNTs）和导电聚合物的 N-MWs 电子生物传感器在与生物分子结合时表现出场效应和电阻变化。还评估了 N-MWs 的尺寸对传感器灵敏度的影响。
