Baxendale Sallie, Heaney Dominic, Rugg-Gunn Fergus, Friedland Daniel
Department of Clinical and Experimental Epilepsy, University College London, Institute of Neurology, London, UK
Department of Clinical Neurology, University College London Hospitals NHS Foundation Trust, London, UK.
Pract Neurol. 2019 Dec;19(6):476-482. doi: 10.1136/practneurol-2018-002113. Epub 2019 Jun 13.
This review examines the clinical and neuroradiological features of traumatic brain injury that are most frequently associated with persistent cognitive complaints. Neuropsychological outcomes do not depend solely on brain injury severity but result from a complex interplay between premorbid factors, the extent and nature of the underlying structural damage, the person's neuropsychological reserve and the impact of non-neurological factors in the recovery process. Brain injury severity is only one of these factors and has limited prognostic significance with respect to neuropsychological outcome. We examine the preinjury and postinjury factors that interact with the severity of a traumatic brain injury to shape outcome trajectories. We aim to provide a practical base on which to build discussions with the patient and their family about what to expect following injury and also to plan appropriate neurorehabilitation.
本综述探讨了与持续性认知主诉最常相关的创伤性脑损伤的临床和神经放射学特征。神经心理学结果并非仅取决于脑损伤的严重程度，而是由病前因素、潜在结构损伤的程度和性质、个体的神经心理学储备以及恢复过程中非神经因素的影响之间复杂的相互作用所导致。脑损伤严重程度只是这些因素之一，对于神经心理学结果的预后意义有限。我们研究了与创伤性脑损伤严重程度相互作用以塑造预后轨迹的伤前和伤后因素。我们旨在提供一个实用的基础，以便与患者及其家属就受伤后的预期情况进行讨论，并规划适当的神经康复治疗。
