胶质纤维酸性蛋白血清水平作为缺血性中风临床结局的预测指标
Glial Fibrillary Acidic Protein Serum Level as a Predictor of Clinical Outcome in Ischemic Stroke.
作者信息
Puspitasari Vivien, Gunawan Pricilla Yani, Wiradarma Hugo Dwiputra, Hartoyo Vinson
机构信息
Universitas Pelita Harapan, Tangerang, Indonesia.
出版信息
Open Access Maced J Med Sci. 2019 May 14;7(9):1471-1474. doi: 10.3889/oamjms.2019.326. eCollection 2019 May 15.
BACKGROUND
Glial Fibrillary Acidic Protein (GFAP) is a protein produced by astrocytes in response to brain injury, which then penetrates the cerebrospinal fluid and the blood stream.
AIM
We sought to determine whether GFAP serum level in acute ischemic stroke could predict clinical outcome.
METHODS
As much as 64 patients with first-ever ischemic stroke had their GFAP serum level measured at 72 hours after onset. The National Institute of Health Stroke Scale (NIHSS) was assessed during the 72 hours of onset, the seventh day, and followed up 1 month after.
RESULTS
There were 46 men and 18 women included in the study. Mean age was 58.3 years old, and nearly half of them (46.9%) were between 50-59 years old. More than half (58.7%) presented with moderate to a severe stroke and mean GFAP serum level was 0.113 ± 0.029 ng/mL. GFAP serum levels had a significant correlation with NIHSS after 1 month (p = 0.04, r = 0.259).
CONCLUSION
There is a significant correlation between GFAP serum levels with stroke severity scale after 1 month of stroke onset.
背景
胶质纤维酸性蛋白（GFAP）是星形胶质细胞在脑损伤后产生的一种蛋白质，随后会渗透到脑脊液和血流中。
目的
我们试图确定急性缺血性卒中患者血清GFAP水平是否能够预测临床结局。
方法
64例首次发生缺血性卒中的患者在发病72小时时检测血清GFAP水平。在发病72小时内、第7天以及发病后1个月进行随访时评估美国国立卫生研究院卒中量表（NIHSS）。
结果
本研究纳入46例男性和18例女性。平均年龄为58.3岁，其中近一半（46.9%）年龄在50 - 59岁之间。超过一半（58.7%）表现为中度至重度卒中，血清GFAP平均水平为0.113±0.029 ng/mL。发病1个月后，血清GFAP水平与NIHSS有显著相关性（p = 0.04，r = 0.259）。
结论
卒中发病1个月后，血清GFAP水平与卒中严重程度量表之间存在显著相关性。
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