Amalia Lisda
Department of Neurology, The First Affiliated Hospital of Faculty of Medicine, Universitas Padjadjaran/RSUP dr. Hasan Sadikin, Bandung, Indonesia.
J Inflamm Res. 2021 Dec 30;14:7501-7506. doi: 10.2147/JIR.S342097. eCollection 2021.
Blockage of the cerebral arteries due to thrombosis and embolism resulting in decreased blood flow to the brain, reduced oxygen supply to the brain, resulting in neuronal damage and causes astrocyte cells to secrete glial fibrillary acidic protein (GFAP). The objective of this study was to determine the correlation between GFAP levels serum and clinical outcome in patients with acute ischemic stroke.
This was observational with a cross-sectional design on acute ischemic stroke patients confirmed by CT scans and divided into large vessel occlusion and small-vessel occlusion. Clinical outcome was measured using the National Institutional Health Stroke Scale (NIHSS) tool. Statistical analysis uses Spearman's rank correlation test and Mann Whitney's test, significant if p < 0.05.
After collecting 33 research subjects, we found 16 people with large vessel occlusion and 17 people with small vessel occlusion. Serum GFAP levels were 0.2-1.9 ng/mL, 9.1% with a mild neurological deficit, 45.45% were moderate neurological deficits, and 45.45% were severe neurological deficits. There was a significant positive correlation (r = 0.522; p = 0.002) between serum GFAP levels and the degree of neurological deficit in ischemic stroke patients. There was a statistically significant difference between serum GFAP levels in ischemic stroke patients with CT scan results of large artery occlusion compared to small artery occlusion (0.7 vs 0.4ng/mL; p = 0.001).
There was a positive correlation between GFAP level serum and NIHSS score on acute ischemic stroke. The higher the value of GFAP serum level, the higher the value for NIHSS and correlated with stroke severity and the extent of brain damage in ischemic stroke patients.
血栓形成和栓塞导致脑动脉阻塞，致使脑部血流减少，脑氧供应降低，进而造成神经元损伤，并促使星形胶质细胞分泌胶质纤维酸性蛋白（GFAP）。本研究的目的是确定急性缺血性中风患者血清中GFAP水平与临床结局之间的相关性。
本研究为观察性研究，采用横断面设计，研究对象为经CT扫描确诊的急性缺血性中风患者，分为大血管闭塞组和小血管闭塞组。使用美国国立卫生研究院卒中量表（NIHSS）工具测量临床结局。统计分析采用Spearman等级相关检验和Mann Whitney检验，p<0.05具有统计学意义。
收集33例研究对象后，我们发现16例大血管闭塞患者和17例小血管闭塞患者。血清GFAP水平为0.2 - 1.9 ng/mL，9.1%为轻度神经功能缺损，45.45%为中度神经功能缺损，45.45%为重度神经功能缺损。缺血性中风患者血清GFAP水平与神经功能缺损程度之间存在显著正相关（r = 0.522；p = 0.002）。与小动脉闭塞的缺血性中风患者相比，CT扫描结果为大动脉闭塞的缺血性中风患者血清GFAP水平存在统计学显著差异（0.7 vs 0.4ng/mL；p = 0.001）。
急性缺血性中风患者血清GFAP水平与NIHSS评分之间存在正相关。血清GFAP水平值越高，NIHSS值越高，且与缺血性中风患者的中风严重程度和脑损伤程度相关。
