Nemavhola Fulufhelo
Department of Mechanical and Industrial Engineering, School of Engineering, College of Science, Engineering and Technology, University of South Africa, Florida, South Africa.
Heliyon. 2019 Jun 6;5(6):e01841. doi: 10.1016/j.heliyon.2019.e01841. eCollection 2019 Jun.
Computational modelling may improve the fundamental understanding of various mechanisms of diseases more particularly related to clinical challenges. In this study the effect of remodeling infarct presence in the left ventricle on the interventricular septal wall is studied using the finite element methods.
In this study, two rat heart (one model with healthy myocardium and one model with remodeling free wall and healthy septal wall) with magnetic resonance imaging data was gathered to reconstruct three-dimensional (3D) rat heart models. 3D data points from Segment® were imported into SolidEdge® for creation of 3D rat heart models. Abaqus® was used for finite element modeling.
The strain in the healthy interventricular septum of the infarcted left ventricle wall increased when compared to the healthy interventricular septum in the healthy left ventricle. Similarly, the average stress in the healthy left ventricle was observed to have increased on the healthy the interventricular septum where the free wall is subjected to remodeling infarct. When comparing the infarcted models to the healthy model, it was found that the average strain had greatly increased by up to 50.0 %.
The remodeling infarct in the left ventricle has an impact on the healthy interventricular septal wall. Even though the interventricular septal wall was modelled as healthy, it was observed that it has undergone considerable changes in stresses and strains in circumferential and longitudinal direction. The observed changes in myocardial stresses and strains may result in poor global functioning of the heart.
计算建模可增进对各种疾病机制的基本理解，尤其是与临床挑战相关的机制。在本研究中，使用有限元方法研究了左心室梗死重塑对室间隔壁的影响。
在本研究中，收集了两只大鼠心脏（一个是健康心肌模型，另一个是游离壁重塑且室间隔壁健康的模型）的磁共振成像数据，以重建三维（3D）大鼠心脏模型。来自Segment®的3D数据点被导入SolidEdge®以创建3D大鼠心脏模型。Abaqus®用于有限元建模。
与健康左心室中的健康室间隔相比，梗死左心室壁的健康室间隔中的应变增加。同样，在游离壁发生重塑梗死的健康室间隔上，观察到健康左心室的平均应力增加。将梗死模型与健康模型进行比较时，发现平均应变大幅增加，最高可达50.0%。
左心室的梗死重塑对健康的室间隔壁有影响。尽管室间隔壁被建模为健康，但观察到它在圆周和纵向方向上的应力和应变发生了相当大的变化。观察到的心肌应力和应变变化可能导致心脏整体功能不佳。
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