School of Ethnic Medicine , Guizhou Minzu University , Guiyang 550025 , People's Republic of China.
The Key Laboratory of Chemistry for Natural Product of Guizhou Province and Chinese Academy of Sciences , Guiyang 550002 , People's Republic of China.
Org Lett. 2019 Jul 5;21(13):5051-5054. doi: 10.1021/acs.orglett.9b01643. Epub 2019 Jun 14.
Ochrocephalamines B-D (1-3), composed of fused quinolizidine and octahydroquinoline rings, were isolated from Oxytropis ochrocephala Bunge. Ochrocephalamine B (1) has a unique bridged tetracyclic ring skeleton fused with a lactam ring. The structures of 1-3 were elucidated using spectroscopic and computational approaches. Ochrocephalamine C (2) and D (3) demonstrated potent anti-HBV activities and are more potent against the secretion of HBeAg than that of HBsAg.
从黄花棘豆中分离得到的稠合的喹诺里西啶和八氢喹啉环组成的ochrocephalamines B-D（1-3）。ochrocephalamine B（1）具有独特的桥环四环骨架与内酰胺环稠合。通过光谱和计算方法阐明了 1-3 的结构。ochrocephalamine C（2）和 D（3）表现出很强的抗乙肝病毒活性，对 HBeAg 的分泌抑制作用强于 HBsAg。
