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本文引用的文献

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Synthesis and biological evaluation of sophoridinol derivatives as a novel family of potential anticancer agents.槐定醇衍生物作为新型潜在抗癌剂家族的合成与生物学评价
ACS Med Chem Lett. 2014 Sep 22;5(11):1225-9. doi: 10.1021/ml500289h. eCollection 2014 Nov 13.
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Synthesis, characterization and in vitro anti-tumor activities of matrine derivatives.苦参碱衍生物的合成、表征及体外抗肿瘤活性研究。
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Synthesis, structure-activity relationship and biological evaluation of anticancer activity for novel N-substituted sophoridinic acid derivatives.新型 N-取代槐定碱衍生物的合成、构效关系及抗癌活性的生物评价。
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Design and synthesis of oxymatrine analogues overcoming drug resistance in hepatitis B virus through targeting host heat stress cognate 70.通过靶向宿主热应激同源物 70 克服乙型肝炎病毒耐药性的氧化苦参碱类似物的设计与合成
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LC-MS characterization of efficacy substances in serum of experimental animals treated with Sophora flavescens extracts.苦参提取物处理的实验动物血清中功效物质的液相色谱-质谱联用表征
Biomed Chromatogr. 2007 Jun;21(6):655-60. doi: 10.1002/bmc.805.
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Supercritical fluid extraction of quinolizidine alkaloids from Sophora flavescens Ait. and purification by high-speed counter-current chromatography.从苦参中超临界流体萃取喹诺里西啶生物碱并通过高速逆流色谱法进行纯化。
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Loco intoxication: indolizidine alkaloids of spotted locoweed (Astragalus lentiginosus).局部中毒：斑点疯草（黄芪属扁豆状黄芪）中的吲哚里西啶生物碱。
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黄花棘豆生物碱及槐定碱衍生物对癌细胞系的抗增殖活性

Alkaloids from Oxytropis ochrocephala and antiproliferative activity of sophoridine derivatives against cancer cell lines.

作者信息

Tan Cheng-jian, Zhao Yu, Goto Masuo, Hsieh Kan-Yen, Yang Xiao-ming, Morris-Natschke Susan L, Liu Li-na, Zhao Bao-yu, Lee Kuo-Hsiung

机构信息

Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, United States; College of Chemistry and Environment, Guizhou Minzu University, Guiyang 550025, People's Republic of China.

Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, United States.

出版信息

Bioorg Med Chem Lett. 2016 Mar 1;26(5):1495-7. doi: 10.1016/j.bmcl.2015.09.010. Epub 2015 Sep 5.

DOI:10.1016/j.bmcl.2015.09.010
PMID:26865176
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4877041/
Abstract

Ten alkaloids (1-10), with sophoridine (1) as the most abundant component, were obtained from the whole plants of Oxytropis ochrocephala Bunge. Furthermore, eight new sophoridine derivatives (11-16, 20, 21), with modification on the C-14 position of 1 were synthesized. All compounds (1-16, 20, 21) were evaluated for antiproliferative activity against five human tumor cell lines. Among them, the newly synthesized derivative 20 exhibited the best inhibitory activity against the tested cell lines. Its activity was increased by more than fourfold as compared with parent compound 1.

摘要

从黄花棘豆全草中获得了10种生物碱（1-10），其中槐定碱（1）含量最高。此外，还合成了8种对1的C-14位进行修饰的新槐定碱衍生物（11-16、20、21）。对所有化合物（1-16、20、21）针对5种人类肿瘤细胞系的抗增殖活性进行了评估。其中，新合成的衍生物20对测试的细胞系表现出最佳抑制活性。与母体化合物1相比，其活性提高了四倍多。