Department of Chemical Engineering , Kyushu University , 744 Motooka , Nishi-ku, Fukuoka 819-0395 , Japan.
Department of Biosciences and Informatics , Keio University , 3-14-1 Hiyoshi , Kohoku-ku, Yokohama , Kanagawa 223-8522 , Japan.
Biomacromolecules. 2019 Jul 8;20(7):2763-2769. doi: 10.1021/acs.biomac.9b00515. Epub 2019 Jun 26.
Synthetic glyco-ligands are promising candidates for effective nanomedicines against pathogens. Glycopolymers bearing sialyl-oligosaccharides interact with hemagglutinin present on the surface of influenza viruses. In designing new glycopolymers that further enhance the interaction with viruses, both static and dynamic properties of the glycopolymers should be considered. In this report, we evaluated the correlation between dynamic properties of glycopolymers and their interaction with the influenza virus. Glycopolymers with pendant sialyllactoses and various linker structures were synthesized, and their molecular mobility was determined by proton spin-spin relaxation time measurements. The molecular mobility of the glycounits increased as the length of the linker structures increased. Interestingly, glycopolymers with the medium-length linker structure exhibited the strongest interaction with the influenza virus, suggesting that optimal molecular mobility is required for maximizing multivalent interactions with the target.
合成糖基配体是有前途的抗病原体纳米药物候选物。带有唾液酸寡糖的糖聚合物与流感病毒表面的血凝素相互作用。在设计进一步增强与病毒相互作用的新型糖聚合物时，应考虑糖聚合物的静态和动态特性。在本报告中，我们评估了糖聚合物的动态特性与其与流感病毒相互作用之间的相关性。合成了带有侧链唾液乳糖和各种连接子结构的糖聚合物，并通过质子自旋-自旋弛豫时间测量来确定其分子迁移率。随着连接子结构长度的增加，糖单元的分子迁移率增加。有趣的是，具有中长链连接子结构的糖聚合物与流感病毒表现出最强的相互作用，这表明需要最佳的分子迁移率来最大限度地提高与靶标的多价相互作用。
