Department of Chemistry, Durham University, Durham DH1 3LE, United Kingdom.
Centre for Glycoscience and School of Chemical and Physical Sciences, Keele University, Keele, Staffordshire ST5 5BG, United Kingdom.
J Am Chem Soc. 2024 Oct 9;146(40):27215-27232. doi: 10.1021/jacs.4c08818. Epub 2024 Sep 28.
Multivalent interactions between receptors and glycans play an important role in many different biological processes, including pathogen infection, self-recognition, and the immune response. The growth in the number of tools and techniques toward the assembly of multivalent glycoconjugates means it is possible to create synthetic systems that more and more closely resemble the diversity and complexity we observe in nature. In this Perspective we present the background to the recognition and binding enabled by multivalent interactions in nature, and discuss the strategies used to construct synthetic glycoconjugate equivalents. We highlight key discoveries and the current state of the art in their applications to glycan arrays, vaccines, and other therapeutic and diagnostic tools, with an outlook toward some areas we believe are of most interest for future work in this area.
受体和聚糖之间的多价相互作用在许多不同的生物过程中发挥着重要作用，包括病原体感染、自我识别和免疫反应。用于组装多价糖缀合物的工具和技术的数量不断增加，这意味着我们有可能创建越来越接近自然界中观察到的多样性和复杂性的合成系统。在本观点中，我们介绍了自然界中多价相互作用所实现的识别和结合的背景，并讨论了用于构建合成糖缀合物等效物的策略。我们重点介绍了在糖缀合物阵列、疫苗和其他治疗和诊断工具中的应用方面的关键发现和当前的技术水平，并展望了我们认为该领域未来工作最感兴趣的一些领域。
