Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA; Sandra and Edward Meyer Cancer Center, New York, NY, USA; Department of Dermatology, Yale School of Medicine, New Haven, CT, USA; Université Paris Descartes/Paris V, Paris, France.
Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Cell. 2019 Jun 13;177(7):1682-1699. doi: 10.1016/j.cell.2019.05.026.
Macroautophagy (herein referred to as autophagy) is an evolutionary ancient mechanism that culminates with the lysosomal degradation of superfluous or potentially dangerous cytosolic entities. Over the past 2 decades, the molecular mechanisms underlying several variants of autophagy have been characterized in detail. Accumulating evidence suggests that most, if not all, components of the molecular machinery for autophagy also mediate autophagy-independent functions. Here, we discuss emerging data on the non-autophagic functions of autophagy-relevant proteins.
自噬（在此称为自噬）是一种古老的进化机制，最终导致多余或潜在危险的细胞质物质被溶酶体降解。在过去的 20 年中，几种自噬变体的分子机制已被详细阐明。越来越多的证据表明，自噬分子机制的大多数（如果不是全部）成分也介导非自噬依赖性功能。在这里，我们讨论了与自噬相关蛋白的非自噬功能的新出现的数据。
Zotero 插件
