Center for Craniofacial Research, Department of Diagnostic and Biomedical Sciences, School of Dentistry, University of Texas Health Science Center at Houston, Houston, TX 77054, USA.
Pediatric Research Center, McGovern Medical School, University of Texas Health Science Center, Houston, TX 77030, USA.
Genes (Basel). 2019 Jun 13;10(6):450. doi: 10.3390/genes10060450.
In recent years, the knowledge generated by decoding the human genome has allowed groundbreaking genetic research to better understand genomic architecture and heritability in healthy and disease states. The vast amount of data generated over time and yet to be generated provides the basis for translational research towards the development of preventive and therapeutic strategies for many conditions. In this special issue, we highlight the discoveries of disease-associated and protective DNA variations in common human diseases and developmental disorders.
近年来，人类基因组解码所产生的知识使得开创性的遗传研究能够更好地理解健康和疾病状态下的基因组结构和遗传性。随着时间的推移产生的大量数据和尚未产生的数据为开发许多疾病的预防和治疗策略的转化研究提供了基础。在本期特刊中，我们重点介绍了常见人类疾病和发育障碍中与疾病相关和保护性的 DNA 变异的发现。
