Y 染色体、高血压和心血管疾病：炎症是答案吗？
Y Chromosome, Hypertension and Cardiovascular Disease: Is Inflammation the Answer?
机构信息
Department of Pharmacology, Monash University, Clayton, Victoria 3800, Australia.
Baker IDI Heart and Diabetes Institute, Melbourne, Victoria 3004, Australia.
出版信息
Int J Mol Sci. 2019 Jun 13;20(12):2892. doi: 10.3390/ijms20122892.
Abstract
It is now becomingly increasingly evident that the functions of the mammalian Y chromosome are not circumscribed to the induction of male sex. While animal studies have shown variations in the Y are strongly accountable for blood pressure (BP), this is yet to be confirmed in humans. We have recently shown modulation of adaptive immunity to be a significant mechanism underpinning Y-chromosome-dependent differences in BP in consomic strains. This is paralleled by studies in man showing Y chromosome haplogroup is a significant predictor for coronary artery disease through influencing pathways of immunity. Furthermore, recent studies in mice and humans have shown that Y chromosome lineage determines susceptibility to autoimmune disease. Here we review the evidence in animals and humans that Y chromosome lineage influences hypertension and cardiovascular disease risk, with a novel focus on pathways of immunity as a significant pathway involved.
摘要
现在越来越明显的是，哺乳动物 Y 染色体的功能不仅限于诱导雄性性别。虽然动物研究表明，Y 染色体的变异强烈影响血压（BP），但这在人类中尚未得到证实。我们最近表明，适应性免疫的调节是支持同基因系中 Y 染色体依赖性血压差异的重要机制。这与人类研究相平行，表明 Y 染色体单倍型通过影响免疫途径，是冠心病的一个重要预测因子。此外，最近在小鼠和人类中的研究表明，Y 染色体谱系决定了自身免疫性疾病的易感性。在这里，我们回顾了动物和人类中的证据，表明 Y 染色体谱系影响高血压和心血管疾病的风险，其中一个新的焦点是免疫途径作为一个重要的参与途径。
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本文引用的文献
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Y-chromosome lineage determines cardiovascular organ T-cell infiltration in the stroke-prone spontaneously hypertensive rat.Y 染色体谱系决定易卒中型自发性高血压大鼠心血管器官 T 细胞浸润。
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Vascular dysfunction in the stroke-prone spontaneously hypertensive rat is dependent on constrictor prostanoid activity and Y chromosome lineage.易卒中型自发性高血压大鼠的血管功能障碍依赖于收缩性前列腺素活性和 Y 染色体谱系。
Clin Sci (Lond). 2018 Jan 16;132(1):131-143. doi: 10.1042/CS20171291.
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