聚乙二醇化花菁染料纳米颗粒作为光热试剂用于控制蚊子和癌细胞。
PEGylated cyanine dye nanoparticles as photothermal agents for mosquito and cancer cell control.
机构信息
Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China; State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China.
出版信息
Bioorg Med Chem Lett. 2019 Aug 15;29(16):2398-2404. doi: 10.1016/j.bmcl.2019.05.057. Epub 2019 May 30.
Conversion of light energy to heat via photothermal conversion agents (PTCAs) is of great interest and has potential applications. Here, we described a heptamethine cyanine (Cy7) dye nanoparticles (Cy7-PEG NPs) prepared from heptamethine cyanine and poly(ethylene glycol) (PEG400) via a simple solvothermal process as novel PTCA. Cy7-PEG NPs have absorption maximum at about 808 nm and good photothermal conversion ability. Upon irradiation, Cy7-PEG NPs can effectively kill living mosquito larva (Aedes albopictus) through heat generation. Furthermore, Cy7-PEG NPs have excellent phototoxic activity to Sf9, HeLa and MCF-7 cells. Our results indicated that Cy7-PEG NPs can be used as controlling agent for mosquito larvae and cancer cells.
通过光热转换剂（PTCAs）将光能转化为热能引起了广泛关注，并具有潜在的应用价值。在这里，我们通过简单的溶剂热法将七甲川菁染料（Cy7）和聚乙二醇（PEG400）制备成七甲川菁染料纳米颗粒（Cy7-PEG NPs），将其作为新型 PTCAs 进行了描述。Cy7-PEG NPs 在约 808nm 处具有最大吸收峰，并且具有良好的光热转换能力。在照射下，Cy7-PEG NPs 通过产热可以有效杀死活体白纹伊蚊幼虫。此外，Cy7-PEG NPs 对 Sf9、HeLa 和 MCF-7 细胞具有优异的光毒性活性。我们的结果表明，Cy7-PEG NPs 可用作控制蚊虫幼虫和癌细胞的试剂。
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