原发性单相重度抑郁症中的去甲肾上腺素能功能与下丘脑-垂体-肾上腺轴活性

Noradrenergic function and hypothalamic-pituitary-adrenal axis activity in primary unipolar major depressive disorder.

作者信息

de Villiers A S, Russell V A, Carstens M E, Aalbers C, Gagiano C A, Chalton D O, Taljaard J J

机构信息

Department of Chemical Pathology, University of Stellenbosch, Tygerberg Hospital, Republic of South Africa.

出版信息

Psychiatry Res. 1987 Oct;22(2):127-40. doi: 10.1016/0165-1781(87)90100-4.

DOI:10.1016/0165-1781(87)90100-4

PMID:3120204

Abstract

Plasma levels of cortisol, norepinephrine (NE), and 3-methoxy-4-hydroxyphenylglycol (MHPG) were found to be significantly higher in 16 drug-free patients with primary, unipolar major depressive disorder than in 20 controls. Plasma free MHPG and basal cortisol levels showed a significant positive correlation in the controls, but not in the patients. There were, however, significant positive correlations between cortisol and NE, as well as between NE and free MHPG levels in the patients. No correlations were observed between patient plasma NE levels and platelet alpha 2-adrenoceptor or lymphocyte beta-adrenoceptor Kd or Bmax values. These peripheral measures of noradrenergic function are proposed as useful markers for patients with primary, unipolar major depressive disorder with melancholia.

摘要

研究发现，16例未服用药物的原发性单相重度抑郁症患者的血浆皮质醇、去甲肾上腺素（NE）和3-甲氧基-4-羟基苯乙二醇（MHPG）水平显著高于20例对照者。在对照组中，血浆游离MHPG和基础皮质醇水平呈显著正相关，但在患者中未观察到这种相关性。然而，在患者中，皮质醇与NE之间以及NE与游离MHPG水平之间存在显著正相关。未观察到患者血浆NE水平与血小板α2-肾上腺素能受体或淋巴细胞β-肾上腺素能受体Kd或Bmax值之间的相关性。这些去甲肾上腺素能功能的外周指标被认为是原发性单相重度抑郁症伴忧郁症患者的有用标志物。