Yuan Yanyan, Chen Gang
Department of Anesthesiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Front Psychol. 2025 Mar 5;16:1485291. doi: 10.3389/fpsyg.2025.1485291. eCollection 2025.
The negative impact of depression on cardiovascular health has drawn much attention. However, the relationship between depressive symptoms and ischemic heart disease (IHD) in postmenopausal women has not been previously reported.
This cross-sectional study analyzed data from the National Health and Nutrition Examination Survey (NHANES) spanning 2005 to 2018, including 6,538 postmenopausal women. Weighted multivariable logistic regression analyses were conducted to examine the independent association between depressive symptoms and IHD.
The fully adjusted model revealed a significant association between depressive symptoms and IHD (OR 1.97, 95% CI [1.24, 3.13]). Subgroup and interaction analyses revealed that depressive symptoms were more strongly linked to IHD risk among younger women, those with lower annual household incomes, non-Hispanic Black women, and individuals with comorbidities such as diabetes and hypercholesterolemia. Moreover, the presence of hypertension moderated the relationship between depressive symptoms and IHD.
Our findings indicate a significant association between depressive symptoms and increased IHD prevalence among postmenopausal women in the United States, with hypertension acting as a moderating factor. These results offer new insights and potential targets for improving cardiovascular health in this population.
抑郁症对心血管健康的负面影响已引起广泛关注。然而，绝经后女性抑郁症状与缺血性心脏病（IHD）之间的关系此前尚未见报道。
这项横断面研究分析了2005年至2018年美国国家健康与营养检查调查（NHANES）的数据，其中包括6538名绝经后女性。采用加权多变量逻辑回归分析来检验抑郁症状与缺血性心脏病之间的独立关联。
完全调整模型显示抑郁症状与缺血性心脏病之间存在显著关联（比值比1.97，95%置信区间[1.24，3.13]）。亚组分析和交互作用分析显示，在年轻女性、家庭年收入较低者、非西班牙裔黑人女性以及患有糖尿病和高胆固醇血症等合并症的个体中，抑郁症状与缺血性心脏病风险的关联更强。此外，高血压的存在调节了抑郁症状与缺血性心脏病之间的关系。
我们的研究结果表明，在美国绝经后女性中，抑郁症状与缺血性心脏病患病率增加之间存在显著关联，高血压是一个调节因素。这些结果为改善该人群的心血管健康提供了新的见解和潜在靶点。
