长链非编码 RNA 在淋巴瘤中的作用：系统评价及临床展望。
Role of long non-coding RNAs in lymphoma: A systematic review and clinical perspectives.
机构信息
Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, 250021, China; School of Medicine, Shandong University, Jinan, Shandong, 250012, China.
Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, 250021, China; School of Medicine, Shandong University, Jinan, Shandong, 250012, China; Shandong Provincial Engineering Research Center of Lymphoma, Jinan, Shandong, 250021, China; Key Laboratory for Kidney Regeneration of Shandong Province, Jinan, Shandong, 250021, China.
出版信息
Crit Rev Oncol Hematol. 2019 Sep;141:13-22. doi: 10.1016/j.critrevonc.2019.05.007. Epub 2019 May 25.
Long non-coding RNAs (lncRNAs), are over 200 nucleotides in length, and they rarely act as templates for protein synthesis. Mounting studies have shown that lncRNAs play a crucial regulatory role in various processes that sustain life, such as epigenetic regulation, cell cycle control, splicing, and post-transcriptional regulation. LncRNAs were aberrantly expressed in most hematological malignancies including lymphoma, participating in tumor suppression or promoting oncogenesis and modulating key genes in different pathways. The specific expression patterns of lncRNAs in lymphoma make them good candidates to be used as diagnostic biomarkers or as therapeutic targets. LncRNAs can be targeted by multiple approaches including nucleic acid therapeutics, CRISPR/Cas genome editing techniques, small molecule inhibitors, and gene therapy. Efforts are made to develop therapeutic strategies aimed at targeting lncRNAs, but there are still some avenues to be covered before they can be applied to the clinical treatment of lymphoma.
长非编码 RNA（lncRNA）长度超过 200 个核苷酸，它们很少作为蛋白质合成的模板。越来越多的研究表明，lncRNA 在维持生命的各种过程中发挥着关键的调节作用，如表观遗传调控、细胞周期控制、剪接和转录后调控。lncRNA 在大多数血液恶性肿瘤中异常表达，包括淋巴瘤，参与肿瘤抑制或促进癌发生，并调节不同途径中的关键基因。lncRNA 在淋巴瘤中的特定表达模式使其成为潜在的诊断生物标志物或治疗靶点。可以通过多种方法靶向 lncRNA，包括核酸治疗、CRISPR/Cas 基因组编辑技术、小分子抑制剂和基因治疗。目前正在努力开发针对 lncRNA 的治疗策略，但在将其应用于淋巴瘤的临床治疗之前，仍有一些途径需要探索。
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