药物对周围神经再生的影响。
The influence of drugs on peripheral nerve regeneration.
机构信息
Department of Plastic and Hand Surgery, University Center of Orthopedics and Trauma Surgery, University Hospital Carl Gustav Carus , Dresden , Germany.
Department of Plastic Surgery, First Surgical Clinic, Emergency District Hospital , Cluj-Napoca , Romania.
出版信息
Drug Metab Rev. 2019 Aug;51(3):266-292. doi: 10.1080/03602532.2019.1632885. Epub 2019 Jun 28.
Currently, there are no established adjuvant drugs for the acceleration of peripheral nerve regeneration. In this paper, we reviewed the literature from the last 10 years and described the drugs proved to accelerate the functional and histological regeneration of the peripheral nerves, either after trauma or in neuropathy experimental models. The vast majority of the studies were experimental with very few small clinical studies, which indicates the need for prospective randomized studies to identify the best drugs to use as adjuvants for nerve regeneration.
目前，还没有用于加速周围神经再生的既定辅助药物。本文回顾了过去 10 年的文献，并描述了已被证明可加速周围神经在创伤后或神经病变实验模型中的功能和组织再生的药物。绝大多数研究都是实验性的，只有很少的小型临床研究，这表明需要进行前瞻性随机研究，以确定可作为神经再生辅助药物的最佳药物。
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