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心源休克中临时机械循环支持设备的应用和结局。

Utilization and Outcomes of Temporary Mechanical Circulatory Support Devices in Cardiogenic Shock.

机构信息

Division of Cardiovascular Medicine, University of Missouri Health Care, Columbia, Missouri.

Medical School of Jordan University of Science and Technology, Irbid, Jordan.

出版信息

Am J Cardiol. 2019 Aug 15;124(4):505-510. doi: 10.1016/j.amjcard.2019.05.032. Epub 2019 May 25.

Abstract

Cardiogenic shock (CS) is associated with high morbidity and mortality despite recent advances in the temporary mechanical circulatory support (MCS) devices. The current utilization and outcomes of these MCS devices with or without vasopressors compared with conventional medical therapy (no-MCS) in CS remain poorly described. The study population was extracted from the 2014 Nationwide Readmissions Database using International Classification of Diseases, Ninth Revision, Clinical Modification codes for CS, temporary MCS devices, and vasopressor infusion. Study end points included in-hospital all-cause mortality, length of index hospital stay (LOS), the likelihood of receiving invasive treatment, postprocedural bleeding, vascular complications, total hospitalization charges, and discharge disposition. A total of 59,148 discharges with a diagnosis of CS were identified (age 67 years; 38.5% female). Temporary MCS devices were utilized in 22.7%. The use of these devices was associated with lower in-hospital all-cause mortality (33.0% vs 39.7%, p <0.01), increased likelihood of invasive therapy (75.7% vs 26.3%, p <0.01), and increased likelihood of being discharged home (24.8% vs 20.6%, p <0.01). However, the MCS group had longer LOS (16.9 vs 12.1 days, p <0.01), higher vascular complications (2.6% vs 1.4%, p <0.01), bleeding (31.2% vs 16.8%, p <0.01), and total hospitalization charges ($374,574 vs $182,045, p <0.01). In conclusion, the use of the temporary MCS devices for the treatment of CS was associated with lower mortality, increased the likelihood of receiving invasive treatment and the likelihood of being discharged home. However, it was associated with higher in-hospital complications, LOS, and hospitalization charges.

摘要

心源性休克(CS)尽管最近在临时机械循环支持(MCS)设备方面取得了进展,但仍与高发病率和死亡率相关。目前,在 CS 中使用这些 MCS 设备(有或没有加压素)与常规药物治疗(无-MCS)的情况以及这些设备的使用情况和结果仍描述不足。使用国际疾病分类,第九修订版,临床修正版的 CS、临时 MCS 设备和加压素输注代码从 2014 年全国再入院数据库中提取研究人群。研究终点包括住院全因死亡率、指数住院时间(LOS)、接受侵入性治疗的可能性、术后出血、血管并发症、总住院费用和出院处置。共确定了 59148 例 CS 诊断出院患者(年龄 67 岁;38.5%为女性)。22.7%的患者使用了临时 MCS 设备。这些设备的使用与较低的住院全因死亡率相关(33.0%比 39.7%,p<0.01),增加了接受侵入性治疗的可能性(75.7%比 26.3%,p<0.01),并增加了出院回家的可能性(24.8%比 20.6%,p<0.01)。然而,MCS 组 LOS 更长(16.9 比 12.1 天,p<0.01),血管并发症更高(2.6%比 1.4%,p<0.01),出血更多(31.2%比 16.8%,p<0.01),总住院费用更高(374574 美元比 182045 美元,p<0.01)。总之,使用临时 MCS 设备治疗 CS 与较低的死亡率相关,增加了接受侵入性治疗的可能性和出院回家的可能性。然而,它与更高的院内并发症、LOS 和住院费用相关。

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