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心源性休克患者应用临时心血管机械支持的利用和结局的社会人口学差异。

Sociodemographic differences in utilization and outcomes for temporary cardiovascular mechanical support in the setting of cardiogenic shock.

机构信息

Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO.

Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO; Center for Health Economics and Policy, Institute for Public Health at Washington University, St. Louis, MO.

出版信息

Am Heart J. 2021 Jun;236:87-96. doi: 10.1016/j.ahj.2020.12.014. Epub 2021 Feb 26.

Abstract

BACKGROUND

Temporary mechanical circulatory support (MCS) devices are increasingly used in cardiogenic shock, but whether sociodemographic differences by sex, race and/or ethnicity, insurance status, and neighborhood poverty exist in the utilization of these devices is unknown.

METHODS

Retrospective cross-sectional study using the National Inpatient Sample for 2012-2017. Logistic regression models were used to examine predictors of use of temporary MCS devices and for in-hospital mortality, clustering by hospital-year.

RESULTS

Our study population included 109,327 admissions for cardiogenic shock. Overall, 14.3% of admissions received an intra-aortic balloon pump, 4.2% a percutaneous ventricular assist device, and 1.8% extracorporeal membranous oxygenation (ECMO). After adjusting for age, comorbidities, and hospital characteristics, use of temporary MCS was lower in women compared to men (adjusted odds ratio [aOR] = 0.76, P < .001), Black patients compared to white ones (aOR = 0.73, P < .001), those insured by Medicare (aOR = 0.75, P < .001), Medicaid (aOR = 0.74, P < .001), or uninsured (aOR = 0.90, P = .015) compared to privately insured, and those in the lowest income neighborhoods (aOR = 0.94, P = .003) versus other neighborhoods. Women, admissions covered by Medicare, Medicaid, or uninsured, and those from low-income neighborhoods also had higher mortality rates even after adjustment for MCS implantation.

CONCLUSIONS

There are differences in the use of temporary MCS in the setting of cardiogenic shock among specific populations within the United States. The growing use of MCS for treating cardiogenic shock highlights the need to better understand its impact on outcomes.

摘要

背景

在心源性休克中,临时机械循环支持(MCS)设备的应用越来越广泛,但这些设备的使用是否存在性别、种族和/或民族、保险状况和社区贫困程度的社会人口学差异尚不清楚。

方法

使用 2012 年至 2017 年国家住院患者样本进行回顾性横断面研究。使用逻辑回归模型检查临时 MCS 设备使用情况和院内死亡率的预测因素,按医院-年份进行聚类。

结果

我们的研究人群包括 109327 例心源性休克入院患者。总体而言,14.3%的入院患者接受了主动脉内球囊泵治疗,4.2%的患者接受了经皮心室辅助装置治疗,1.8%的患者接受了体外膜氧合(ECMO)治疗。在校正年龄、合并症和医院特征后,与男性相比,女性使用临时 MCS 的比例较低(调整后的优势比[aOR] = 0.76,P <.001),黑人患者与白人患者相比(aOR = 0.73,P <.001),医疗保险(aOR = 0.75,P <.001)、医疗补助(aOR = 0.74,P <.001)或无保险(aOR = 0.90,P =.015)的患者,以及收入最低社区(aOR = 0.94,P =.003)的患者。即使在调整了 MCS 植入后,女性、医疗保险、医疗补助或无保险覆盖的入院患者以及来自低收入社区的患者的死亡率仍然更高。

结论

在美国特定人群中心源性休克中,临时 MCS 的使用存在差异。MCS 在心源性休克治疗中的应用不断增加,突出了更好地了解其对结局影响的必要性。

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