Department of Internal Medicine, and Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen 6525GA, the Netherlands; Department of Vascular Medicine, Amsterdam University Medical Centres, University of Amsterdam, 1105AZ Amsterdam, the Netherlands.
Department of Vascular Medicine, Amsterdam University Medical Centres, University of Amsterdam, 1105AZ Amsterdam, the Netherlands.
Cell Metab. 2019 Jul 2;30(1):1-2. doi: 10.1016/j.cmet.2019.05.014. Epub 2019 Jun 13.
Individuals with elevated LDL-cholesterol levels have an increased risk for cardiovascular disease. Despite lipid lowering strategies, however, a significant cardiovascular risk remains. Bekkering et al. show that monocytes from patients with familial hypercholesterolemia have a trained immunity phenotype and that lipid lowering with statins does not revert this pro-inflammatory phenotype.
个体的 LDL-胆固醇水平升高，其心血管疾病的风险也会增加。尽管采取了降脂策略，但仍然存在显著的心血管风险。Bekkering 等人表明，家族性高胆固醇血症患者的单核细胞具有训练免疫表型，而他汀类药物降低血脂并不能逆转这种促炎表型。
