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具有完全囊性表现的移动性脊髓神经鞘瘤。

Mobile Spinal Schwannoma with a Completely Cystic Appearance.

作者信息

Hamabe Fumiko, Soga Shigeyoshi, Imabayashi Hideaki, Matsunaga Ayano, Shinmoto Hiroshi

机构信息

Department of Radiology, National Defense Medical College, Tokorozawa, Saitama, Japan.

Department of Orthopedic Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan.

出版信息

Am J Case Rep. 2019 Jun 17;20:859-863. doi: 10.12659/AJCR.916249.

Abstract

BACKGROUND Spinal schwannomas are benign tumors arising from Schwann cells. Although they have been well described, tumor movement in the spinal canal is an extremely rare finding, and entirely cystic spinal schwannomas have rarely been reported. This is the first report of a spinal schwannoma that simultaneously exhibited both these unusual features. CASE REPORT A 48-year-old female presented with dysuria and right leg pain. Initial magnetic resonance imaging (MRI) revealed a well-delineated intradural cystic lesion at the level of L4-S1 vertebrae that was isointense with cerebrospinal fluid on both T1- and T2-weighted images. A follow-up MRI 6 months later showed that the tumor had moved to the level of L2-L4; it also revealed tortuous configuration of nerve roots of the cauda equina. The tumor was resected, and a diagnosis of schwannoma with extensive cystic degeneration was pathologically confirmed. CONCLUSIONS Various possible mechanisms have been suggested for the mobility of extramedullary tumors. In the present case, MRI findings indicated the cause of the tumor movement might be attributed to the laxity of nerve roots. Besides, it is highly atypical for a schwannoma to present an entirely cystic appearance, and the combination of the 2 extraordinary features made preoperative diagnosis difficult. However, 16 out of 22 (73%) of previously reported mobile spinal tumors were schwannomas, so the differential diagnosis for a mobile spinal tumor should include schwannoma, even when the lesion seems entirely cystic on MRI. To minimize the risk of complications and additional surgical dissection, physicians should acknowledge that spinal tumors can migrate.

摘要

背景

脊髓神经鞘瘤是起源于施万细胞的良性肿瘤。尽管对其已有充分描述,但肿瘤在椎管内移动是极为罕见的发现,而完全囊性的脊髓神经鞘瘤鲜有报道。本文首次报告了同时具备这两种不寻常特征的脊髓神经鞘瘤。

病例报告

一名48岁女性,出现排尿困难及右腿疼痛症状。最初的磁共振成像(MRI)显示,在L4 - S1椎体水平有一个边界清晰的硬膜内囊性病变,在T1加权和T2加权图像上均与脑脊液信号强度相等。6个月后的随访MRI显示肿瘤已移至L2 - L4水平;还显示马尾神经根呈迂曲形态。肿瘤被切除,病理证实为伴有广泛囊性变的神经鞘瘤。

结论

对于髓外肿瘤的移动性,已提出多种可能机制。在本病例中,MRI表现提示肿瘤移动的原因可能是神经根松弛。此外,神经鞘瘤呈现完全囊性外观非常不典型,这两种异常特征同时出现使得术前诊断困难。然而,在先前报道的可移动脊髓肿瘤中,22例中有16例(73%)为神经鞘瘤,因此即使病变在MRI上看似完全囊性,对于可移动脊髓肿瘤的鉴别诊断也应包括神经鞘瘤。为尽量减少并发症风险和额外的手术剥离,医生应认识到脊髓肿瘤可能会迁移。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/683f/6590268/b152220614c1/amjcaserep-20-859-g001.jpg

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