急性实验性变应性脑脊髓炎的磁共振成像
MR of acute experimental allergic encephalomyelitis.
作者信息
Grossman R I, Lisak R P, Macchi P J, Joseph P M
机构信息
Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia 19104.
出版信息
AJNR Am J Neuroradiol. 1987 Nov-Dec;8(6):1045-8.
Acute experimental allergic encephalomyelitis, an animal model of CNS inflammatory and demyelinating disease, was produced in guinea pigs and imaged with MR. Correlation of histopathology with MR revealed acute mononuclear perivascular inflammatory changes and edema corresponding to the high-intensity abnormalities observed on long repetition time (TR) images. Our results suggest that in acute multiple sclerosis the high intensity noted on long TR images may be secondary to associated inflammatory changes rather than to demyelination.
急性实验性变应性脑脊髓炎是一种中枢神经系统炎症和脱髓鞘疾病的动物模型，在豚鼠身上诱发该疾病并用磁共振成像（MR）进行成像。组织病理学与MR的相关性显示，急性单核细胞血管周围炎性改变和水肿与在长重复时间（TR）图像上观察到的高强度异常相对应。我们的结果表明，在急性多发性硬化症中，长TR图像上记录的高强度可能继发于相关的炎症改变而非脱髓鞘。
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