Aguilar E, Bellido C, Aguilar R, Pinilla L, Tejero A, Galaz C F
Department of Physiology, Faculty of Medicine, University of Córdoba, Spain.
Andrologia. 1987 Jan-Feb;19(1):22-31. doi: 10.1111/j.1439-0272.1987.tb01852.x.
Neonatal estrogenization induced in prepubertal males atrophy of the testis and ventral prostate and increased the weight of the seminal vesicles. Atrophy of the testis was probably due to the inhibition of FSH and LH secretion: males estrogenized on day one and sacrificed daily from day six to day fifteen showed lower gonadotropin levels than their respective controls. In addition, daily FSH and LH administration (80 micrograms/100 g BW and 40 micrograms/100 g BW respectively) from day one to day fifteen increased testicular development more effectively in estrogenized than in control males and the differences between the two groups disappeared. Prostate atrophy was due to the decreased testosterone secretion. The reason for the hypertrophy of the seminal vesicles remains unclear: reduction in Prolactin levels due to bromocriptine treatment did not normalize the seminal vesicles weight, indicating that hyperprolactinemia was not the cause. Male rats estrogenized on day one, orchidectomized on day 5 and decapitated on day fifteen also showed hypertrophy in their seminal vesicles. These results indicate that testicular factors, other than testosterone, were not responsible for the vesicular hypertrophy. It seem possible that estrogens might act directly on vesicular growth.
青春期前雄性大鼠经新生儿期雌激素化后，睾丸和前列腺腹侧出现萎缩，精囊重量增加。睾丸萎缩可能是由于促卵泡激素（FSH）和促黄体生成素（LH）分泌受到抑制：在出生第一天进行雌激素化处理，并在第六天至第十五天每天处死的雄性大鼠，其促性腺激素水平低于各自的对照组。此外，从出生第一天至第十五天每天分别给予FSH和LH（分别为80微克/100克体重和40微克/100克体重），与对照雄性大鼠相比，雌激素化雄性大鼠的睾丸发育得到更有效的促进，两组之间的差异消失。前列腺萎缩是由于睾酮分泌减少所致。精囊肥大的原因尚不清楚：用溴隐亭治疗使催乳素水平降低，但并未使精囊重量恢复正常，这表明高催乳素血症不是其原因。在出生第一天进行雌激素化处理、在第五天进行睾丸切除并在第十五天断头处死的雄性大鼠，其精囊也出现肥大。这些结果表明，除睾酮外，睾丸因素并非精囊肥大的原因。雌激素可能直接作用于精囊生长，这似乎是有可能的。
