新生期雌激素化雄性大鼠的青春期前生殖缺陷

Prepuberal reproductive defects in neonatal estrogenized male rats.

作者信息

Bellido C, Gaytán F, Aguilar R, Pinilla L, Aguilar E

出版信息

Biol Reprod. 1985 Sep;33(2):381-7. doi: 10.1095/biolreprod33.2.381.

DOI:10.1095/biolreprod33.2.381

Abstract

Intact Wistar male rats injected on Day 1 with 500 micrograms of estradiol benzoate or olive oil were decapitated on Days 15 and 22 or maintained until adulthood to analyze the balanopreputial separation. Other oil or estradiol-treated rats were orchidectomized on Day 15 and decapitated on Day 22. The neonatal estrogenization produced the following reproductive changes prior to puberty: testis, adrenal, and ventral prostate atrophy; increase in the weights of seminal vesicles and epididymis; decrease in testosterone plasma levels; delayed balanopreputial separation; abolition of luteinizing hormone response to orchidectomy; transient increase in prolactin plasma levels; and blockade in seminal and prostate response to orchidectomy.

摘要

第1天给完整的雄性Wistar大鼠注射500微克苯甲酸雌二醇或橄榄油，分别在第15天和第22天将其断头，或将其饲养至成年以分析阴茎包皮分离情况。其他用橄榄油或雌二醇处理的大鼠在第15天进行去势，并在第22天断头。新生期雌激素化在青春期前产生了以下生殖变化：睾丸、肾上腺和腹侧前列腺萎缩；精囊和附睾重量增加；血浆睾酮水平降低；阴茎包皮分离延迟；对去势的促黄体生成素反应消失；血浆催乳素水平短暂升高；以及对去势的精液和前列腺反应受阻。