维拉帕米可提高贝达喹啉对脓肿分枝杆菌的体外和巨噬细胞内活性。
Verapamil Improves the Activity of Bedaquiline against Mycobacterium abscessus In Vitro and in Macrophages.
机构信息
Institut de Recherche en Infectiologie de Montpellier, Université de Montpellier, CNRS UMR 9004, Montpellier, France.
2I, INSERM, UVSQ, Université Paris-Saclay, Versailles, France.
出版信息
Antimicrob Agents Chemother. 2019 Aug 23;63(9). doi: 10.1128/AAC.00705-19. Print 2019 Sep.
Abstract
Due to intrinsic multidrug resistance, pulmonary infections with are extremely difficult to treat. Previously, we demonstrated that bedaquiline is highly effective against both and Here, we report that verapamil improves the efficacy of bedaquiline activity against clinical isolates and low-level resistant strains, both and in macrophages. Verapamil may have clinical potential as adjunctive therapy provided that sufficiently high doses can be safely achieved.
摘要
由于内在的多药耐药性，肺部感染 极其难以治疗。此前，我们已经证明，贝达喹啉对 和 都具有高度疗效。在这里，我们报告维拉帕米可提高贝达喹啉对 临床分离株和低水平耐药株的疗效，不论是 在巨噬细胞中。只要能安全地实现足够高的剂量，维拉帕米就可能具有临床应用潜力，作为辅助治疗手段。
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