Pande G K, Reddy V M, Kar P, Sahni P, Berry M, Tandon B N, Nundy S
All India Institute of Medical Sciences, New Delhi.
Br Med J (Clin Res Ed). 1987 Oct 31;295(6606):1115-7. doi: 10.1136/bmj.295.6606.1115.
Between 1976 and 1984, 136 patients with portal hypertension due to extrahepatic obstruction were operated on. Twenty two patients had emergency and 114 elective operations. The operative mortality was 9% and 1%, respectively. Altogether 117 patients (86%) were followed up for from two to 10 years: 17 rebled, none developed encephalopathy or sepsis after splenectomy, and 90% and 75% were alive at five and 10 years respectively. Unlike endoscopic sclerotherapy and treatment with propranolol, operative treatment of variceal bleeding can usually be completed during one admission and carries a low mortality and a fairly low morbidity. Operation seems to be the best form of treatment for poor patients living far from medical facilities in developing countries and may be the treatment of choice in developed countries as well.
1976年至1984年间,136例因肝外梗阻导致门静脉高压的患者接受了手术治疗。其中22例为急诊手术,114例为择期手术。手术死亡率分别为9%和1%。共有117例患者(86%)接受了为期2至10年的随访:17例再次出血,脾切除术后无一例发生脑病或败血症,5年和10年生存率分别为90%和75%。与内镜硬化治疗和普萘洛尔治疗不同,曲张静脉出血的手术治疗通常可在一次住院期间完成,死亡率低且发病率相当低。手术似乎是发展中国家远离医疗设施的贫困患者的最佳治疗方式,在发达国家也可能是首选治疗方法。