Faculty of Health Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.
Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNS), European Graduate School of Neuroscience (EURON), Maastricht University Medical Centre, Maastricht, The Netherlands.
Soc Psychiatry Psychiatr Epidemiol. 2019 Sep;54(9):1045-1054. doi: 10.1007/s00127-019-01711-z. Epub 2019 Jun 17.
Whilst childhood trauma (CT) is a known risk factor across the spectrum of psychosis expression, little is known about possible interplay with genetic liability.
The TwinssCan Study collected data in general population twins, focussing on expression of psychosis at the level of subthreshold psychotic experiences. A multilevel mixed-effects linear regression analysis was performed including 745 subjects to assess the interaction between genetic liability and CT. The Symptom Checklist-90 (SCL-90-R) score of the co-twin was used as an indirect measure of genetic liability to psychopathology, while the Childhood Trauma Questionnaire Short-Form (CTQ-SF) was used to assess CT in the domains of physical, emotional and sexual abuse, as well as physical and emotional neglect. The Community Assessment of Psychic Experience (CAPE) questionnaire was used to phenotypically characterize psychosis expression.
In the model using the CAPE total score, the interaction between CT and genetic liability was close to statistical significance (χ = 5.6, df = 2, p = 0.06). Analyses of CAPE subscales revealed a significant interaction between CT and genetic liability (χ = 8.8, df = 2, p = 0.012) for the CAPE-negative symptoms subscale, but not for the other two subscales (i.e. positive and depressive).
The results suggest that the impact of CT on subthreshold expression of psychosis, particularly in the negative subdomain, may be larger in the co-presence of significant genetic liability for psychopathology.
虽然儿童创伤 (CT) 是精神病表达谱中已知的风险因素，但对于其与遗传易感性的可能相互作用知之甚少。
TwinssCan 研究在一般人群双胞胎中收集数据，重点关注亚临床精神病体验水平的精神病表达。对包括 745 名受试者的多水平混合效应线性回归分析进行了评估，以评估遗传易感性和 CT 之间的相互作用。同卵双胞胎的症状清单-90（SCL-90-R）评分被用作精神病理学遗传易感性的间接衡量标准，而童年创伤问卷短式（CTQ-SF）则用于评估身体、情感和性虐待以及身体和情感忽视等领域的 CT。使用社区心理体验评估 (CAPE) 问卷对精神病表达进行表型特征描述。
在使用 CAPE 总分的模型中，CT 和遗传易感性之间的相互作用接近统计学意义（χ=5.6，df=2，p=0.06）。CAPE 子量表的分析显示，CT 和遗传易感性之间存在显著的相互作用（χ=8.8，df=2，p=0.012），对于 CAPE 阴性症状子量表，但对于其他两个子量表（即阳性和抑郁）则没有。
研究结果表明，CT 对亚临床精神病表达的影响，特别是在阴性子领域，在存在显著的精神病理学遗传易感性时可能更大。
