Departments of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Department of Pediatrics, The Catholic University of Korea Deajeon St. Mary's Hospital, 64 Daeheung-ro, Jung-gu, Daejeon, 34943, Republic of Korea.
Clin Rheumatol. 2019 Oct;38(10):2811-2818. doi: 10.1007/s10067-019-04628-9. Epub 2019 Jun 8.
It is unknown whether epidemiological or clinical characteristics of Henoch-Schönlein purpura (HSP) have changed over time. This study aimed at evaluating the epidemiological and clinical changes of HSP during 3 decades.
We retrospectively analyzed the data of 515 children with HSP (0-15 years of age) between 1987 and 2015. We compared the two HSP patient groups: those admitted from 1987 to 1996 (group A, 238 cases) and those admitted from 2006 to 2015 (group B, 98 cases), apart a decade.
In total 515 patients, the mean age was 6.5 ± 3.0 years and the male-to-female ratio was 1.2:1 (278:237). The age distribution showed a peak at age 5 with a bell-shaped distribution pattern. The annual number of cases varied in each year with a trend of reduced cases in the recent decade. There were less cases during the summer season. Purpura, gastrointestinal involvement, joint involvement, and renal involvement were found in 100%, 56%, 38%, and 18% of the patients, respectively. In comparison between the two groups, there were similar findings in mean age, age distribution, and seasonal distribution. However, the hospitalization stay was longer, and the proportion of recurrent cases (14 cases vs. 0 case) and proteinuria (15% vs. 3%) were higher in the group A than in the group B.
Long-term epidemiologic features of HSP were similar to those in other countries. Clinical manifestations of HSP showed a trend towards a less severe clinical phenotype over time in Deajeon, Korea. Key Points • It is unknown whether epidemiological and clinical traits of Henoch-Schönlein purpura (HSP) have changed over time. • We reported that clinical manifestations of HSP have changed to milder phenotype through a long-term observation of three decades at a single hospital in Daejeon, South Korea. • Clinical phenotype of infection-related diseases, including HSP, may be changed over time, and the etiology and the reason of clinical changes over time remain to be solved.
尚不清楚过敏性紫癜（HSP）的流行病学或临床特征是否随时间发生了变化。本研究旨在评估 30 年来 HSP 的流行病学和临床变化。
我们回顾性分析了 1987 年至 2015 年间 515 例 HSP 患儿（0-15 岁）的数据。我们比较了两组 HSP 患儿：1987 年至 1996 年入院的 238 例（A 组）和 2006 年至 2015 年入院的 98 例（B 组），两组相差 10 年。
在 515 例患者中，平均年龄为 6.5±3.0 岁，男女比例为 1.2:1（278:237）。年龄分布呈钟形分布，高峰在 5 岁。每年的病例数各不相同，最近十年的病例数呈减少趋势。夏季发病较少。100%的患者出现紫癜，56%的患者出现胃肠道受累，38%的患者出现关节受累，18%的患者出现肾脏受累。与两组相比，平均年龄、年龄分布和季节分布相似。然而，A 组的住院时间较长，复发病例（14 例 vs. 0 例）和蛋白尿（15% vs. 3%）的比例高于 B 组。
过敏性紫癜的长期流行病学特征与其他国家相似。过敏性紫癜的临床表现呈逐渐减轻的趋势。
