Amsterdam Rheumatology and Immunology Center/Reade , Amsterdam , The Netherlands.
Department of Rheumatology, Antonius Hospital , Sneek , The Netherlands.
Scand J Rheumatol. 2019 Sep;48(5):345-352. doi: 10.1080/03009742.2019.1600718. Epub 2019 Jun 18.
: In 2011, we started to offer cardiovascular (CV) risk screening to rheumatoid arthritis (RA) patients with a high CV risk. After 1 year, we assessed whether patients labelled as high CV risk had started preventive treatment when indicated, and whether the CV risk score had changed. : CV risk screening was performed in both a large outpatient rheumatology clinic and a general hospital in the Netherlands, and the general practitioner or the internist was informed about the results of the CV screening, including specific advice on the initiation or adjustment of cardiopreventive drugs. National guidelines were used to assess how many patients were eligible for preventive treatment. After 1 year, CV risk, lifestyle, and treatment were re-evaluated. Patients with a history of CV disease at baseline or who experienced a CV event during follow-up were excluded from the analyses. : A high 10 year CV risk (> 20%) was present in 58%, and 55% had an indication for anti-hypertensives, statins, or both. At follow-up, cardiopreventive drug treatment had been started or adjusted in only one-third of patients with an indication for treatment. After screening, 42% of patients reported having changed their lifestyle, through more exercise (24%), diet adaption (20%), and weight loss (11%). : Despite clear guidelines to improve CV risk, the results of a programme comprising active screening, targeted advice, and referral to the general practitioner or internist prove that primary prevention remains a major challenge in high-risk RA patients.
2011 年,我们开始为心血管风险较高的类风湿关节炎患者提供心血管风险筛查。1 年后,我们评估了高心血管风险患者是否已开始进行有指征的预防治疗,以及心血管风险评分是否发生了变化。
心血管风险筛查在荷兰的一家大型门诊风湿病诊所和一家综合医院进行,全科医生或内科医生会获知心血管筛查的结果,包括关于启动或调整心脏预防药物的具体建议。我们使用国家指南来评估有多少患者有资格接受预防治疗。1 年后,重新评估了心血管风险、生活方式和治疗情况。患有基线期心血管疾病史或在随访期间发生心血管事件的患者被排除在分析之外。
10 年心血管风险较高(>20%)的患者占 58%,55%的患者有抗高血压药物、他汀类药物或两者的适应证。在随访时,有治疗指征的患者中仅有三分之一开始或调整了心脏预防药物治疗。筛查后,42%的患者报告通过增加运动(24%)、饮食调整(20%)和减肥(11%)改变了生活方式。
尽管有明确的改善心血管风险的指南,但一项包括主动筛查、有针对性的建议以及转介给全科医生或内科医生的计划的结果表明,初级预防仍然是高风险类风湿关节炎患者面临的主要挑战。