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Mol Cell Oncol. 2019 May 7;6(4):1610323. doi: 10.1080/23723556.2019.1610323. eCollection 2019.
2
Cut-and-Run: A Distinct Mechanism by which V(D)J Recombination Causes Genome Instability.断裂-重接：V(D)J 重组导致基因组不稳定性的一种独特机制。
Mol Cell. 2019 May 2;74(3):584-597.e9. doi: 10.1016/j.molcel.2019.02.025. Epub 2019 Mar 21.
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V(D)J targeting mistakes occur at low frequency in acute lymphoblastic leukemia.V(D)J靶向错误在急性淋巴细胞白血病中发生频率较低。
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The DDE motif in RAG-1 is contributed in trans to a single active site that catalyzes the nicking and transesterification steps of V(D)J recombination.RAG-1中的DDE基序以反式作用于一个单一的活性位点，该位点催化V(D)J重组的切口和转酯步骤。
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Cancer Sci. 2021 Jul;112(7):2679-2691. doi: 10.1111/cas.14939. Epub 2021 May 18.

本文引用的文献

1
Cut-and-Run: A Distinct Mechanism by which V(D)J Recombination Causes Genome Instability.断裂-重接：V(D)J 重组导致基因组不稳定性的一种独特机制。
Mol Cell. 2019 May 2;74(3):584-597.e9. doi: 10.1016/j.molcel.2019.02.025. Epub 2019 Mar 21.
2
Chromosomal Loop Domains Direct the Recombination of Antigen Receptor Genes.染色体环结构域指导抗原受体基因的重组。
Cell. 2015 Nov 5;163(4):947-59. doi: 10.1016/j.cell.2015.10.016. Epub 2015 Oct 22.
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RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia.RAG 介导的重组是 ETV6-RUNX1 急性淋巴细胞白血病中致癌重排的主要驱动因素。
Nat Genet. 2014 Feb;46(2):116-25. doi: 10.1038/ng.2874. Epub 2014 Jan 12.
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The response to and repair of RAG-mediated DNA double-strand breaks.RAG 介导的 DNA 双链断裂的响应和修复。
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Chromosomal reinsertion of broken RSS ends during T cell development.T细胞发育过程中断裂的重组信号序列末端的染色体重新插入。
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In vivo reinsertion of excised episomes by the V(D)J recombinase: a potential threat to genomic stability.通过V(D)J重组酶在体内重新插入切除的附加体：对基因组稳定性的潜在威胁。
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Mechanisms of B-cell lymphoma pathogenesis.B细胞淋巴瘤发病机制。
Nat Rev Cancer. 2005 Apr;5(4):251-62. doi: 10.1038/nrc1589.
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Modeling first-hit functions of the t(12;21) TEL-AML1 translocation in mice.小鼠中t(12;21) TEL-AML1易位首次打击功能的建模。
Proc Natl Acad Sci U S A. 2004 Jun 1;101(22):8443-8. doi: 10.1073/pnas.0402063101. Epub 2004 May 20.
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Restraining the V(D)J recombinase.抑制V(D)J重组酶
Nat Rev Immunol. 2003 Aug;3(8):656-66. doi: 10.1038/nri1152.
10
V(D)J recombination: RAG proteins, repair factors, and regulation.V(D)J重排：RAG蛋白、修复因子与调控
Annu Rev Biochem. 2002;71:101-32. doi: 10.1146/annurev.biochem.71.090501.150203. Epub 2001 Nov 9.

由V(D)J重组副产物引发的基因组不稳定。

Genome instability triggered by the V(D)J recombination by-product.

作者信息

Kirkham Christopher M, Boyes Joan

机构信息

Discovery Services, Charles River Laboratories, Inc, Bristol, UK.

School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK.

出版信息

Mol Cell Oncol. 2019 May 7;6(4):1610323. doi: 10.1080/23723556.2019.1610323. eCollection 2019.

DOI:10.1080/23723556.2019.1610323
PMID:31211241
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6548484/
Abstract

A newly identified process by which mistargeted V(D)J recombination could cause genome instability in childhood leukemia has been discovered. In this mechanism, called cut-and-run, the excised DNA by-products of V(D)J recombination are re-bound by the recombinase proteins and erroneously trigger double-strand breaks at multiple locations throughout the genome. Many of these breakpoints co-localize with known chromosome alterations in acute lymphoblastic leukemia (ALL).

摘要

一个新发现的过程表明，错误靶向的V(D)J重组可能导致儿童白血病中的基因组不稳定。在这种被称为“剪切并运行”的机制中，V(D)J重组切除的DNA副产物被重组酶蛋白重新结合，并错误地在整个基因组的多个位置引发双链断裂。许多这些断点与急性淋巴细胞白血病（ALL）中已知的染色体改变共定位。