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2007年至2017年美国前列腺癌诊断与中风之间的关联。

Link between prostate cancer diagnosis and stroke in the United States during 2007-2017.

作者信息

Rethemiotaki Irene, Rethemiotakis Andrew

机构信息

Department of Production Engineering and Management, Technical University of Crete, Chania, Greece.

Department of Agriculture, Technological Educational Institute of Crete, Iraklion, Greece.

出版信息

Arch Med Sci Atheroscler Dis. 2019 May 23;4:e94-e102. doi: 10.5114/amsad.2019.85383. eCollection 2019.

Abstract

INTRODUCTION

The main purpose of this work is to study prostate cancer and stroke in the United States during the years 2007-2017 and to find not only statistically significant predictors for cancer, but also a possible association between prostate cancer and stroke.

MATERIAL AND METHODS

The statistical methods used to derive the results of this work are χ test and one-way analysis of variance (ANOVA), in order to check the statistical significance of prostate cancer in relation to socio-economic factors of patients. In addition, a multivariate logistic regression analysis was used with the odds ratio (OR) to find statistically significant prognostic factors for both prostate cancer and stroke.

RESULTS

According to multiple logistic regression analysis, males who are unemployed but have worked previously have 16 times higher risk of developing prostate cancer, while widowed men have five times higher risk for the occurrence of this type of cancer. In addition, marital status and employment proved to be also prognostic risk factors for stroke.

CONCLUSIONS

Our results describe for the first time the importance of deprivation (of work and partner) as a primary prognostic risk factor for cancer. Moreover, the same factor proved to be the primary prognostic risk factor for stroke as well as for prostate cancer, a fact that implies a possible link between cancer and stroke.

摘要

引言

这项工作的主要目的是研究2007年至2017年期间美国的前列腺癌和中风情况,不仅要找出癌症具有统计学意义的预测因素,还要找出前列腺癌与中风之间可能存在的关联。

材料与方法

用于得出本研究结果的统计方法是χ检验和单因素方差分析(ANOVA),以检验前列腺癌与患者社会经济因素之间的统计学意义。此外,使用多因素逻辑回归分析及比值比(OR)来找出前列腺癌和中风具有统计学意义的预后因素。

结果

根据多因素逻辑回归分析,曾有工作但目前失业的男性患前列腺癌的风险高出16倍,而丧偶男性患此类癌症的风险高出5倍。此外,婚姻状况和就业情况也被证明是中风的预后风险因素。

结论

我们的研究结果首次描述了(工作和伴侣方面的)匮乏作为癌症主要预后风险因素的重要性。此外,同一因素也被证明是中风以及前列腺癌的主要预后风险因素,这一事实意味着癌症与中风之间可能存在联系。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b70/6554749/e0eafd9597a7/AMS-AD-4-36752-g001.jpg

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