Shinoda B A, Mason R G
Biomater Med Devices Artif Organs. 1978;6(4):305-29. doi: 10.3109/10731197809119791.
Heparinized human blood was exposed to the dialysis membranes of commercially available pediatric size hemodialyzers in an in vitro flow circuit. Bloods from normal subjects and from patients with various blood coagulation and platelet function deficiencies were tested in this model system. In most cases, there was a heavy linear deposit of leukocytes on the dialysis membrane overlying support structures. In other areas, the cellular deposit was less uniform and consisted of single platelets, platelet aggregates, leukocytes, and occasional fibrocellular microthrombi. The number of adherent platelets was smaller in tests with blood from patients with congenital afibrinogenemia, factor XII deficiency, severe von Willebrand's disease, and thrombasthenia then in tests with blood from normal subjects or hemophilic patients. Hence, fibrinogen, factor XII, the von Willebrand factor, and a normal platelet plasma membrane appear necessary for adhesion of platelets to dialysis membranes.
在体外流动回路中，将肝素化的人体血液暴露于市售儿科尺寸血液透析器的透析膜。在该模型系统中测试了来自正常受试者以及患有各种凝血和血小板功能缺陷患者的血液。在大多数情况下，透析膜覆盖的支撑结构上有大量白细胞呈线性沉积。在其他区域，细胞沉积不太均匀，由单个血小板、血小板聚集体、白细胞和偶尔的纤维细胞微血栓组成。与正常受试者或血友病患者的血液测试相比，先天性纤维蛋白原血症、因子 XII 缺乏症、重度血管性血友病和血小板无力症患者的血液测试中，粘附的血小板数量较少。因此，纤维蛋白原、因子 XII、血管性血友病因子和正常的血小板质膜似乎是血小板粘附于透析膜所必需的。
